PMID- 18693608
OWN - NLM
STAT- MEDLINE
DCOM- 20081009
LR  - 20131121
IS  - 1025-9589 (Print)
IS  - 1025-9589 (Linking)
VI  - 19
IP  - 4
DP  - 2007 Oct-Dec
TI  - Study of lipoprotein patterns as an atherogenic factor in T2DM patients and their 
      FDRs.
PG  - 89-93
AB  - BACKGROUND: The present study was carried out to determine the lipoprotein 
      patterns as an atherogenic factor in T2DM (Type 2 Diabetes Mellitus) patients and 
      their FDRS (First Degree Relatives). In various previous studies it has been 
      reported that hyperinsulinemia and hyperlipidemia frequently coexist in T2DM 
      patients which indicate that the diabetic state it self is associated with 
      atherogenic lipid disorders. METHOD: The present study included 26 Type 2DM 
      (T2DM) patients and 21 apparently healthy First Degree Relative (FDRs) of T2DM 
      patients. Twenty three age matched control not related to diabetics were also 
      included in the study. RESULTS: The BMI in male patients and FDRs were 
      significantly higher as compared to controls but no significant difference was 
      seen among the BMI of female FDRs. Fasting plasma glucose (FPG) levels of T2DM 
      patients were significantly higher but no significant difference was observed 
      among the FDRs and controls. FPG did not show any significant correlation with 
      the BMI in diabetic patients, FDRs and controls. The lipid profile of patients 
      showed no significant difference, except the mean LDL-Chol of female patients was 
      significantly higher as compared to female controls. HDL-Chol of males FDRs was 
      significantly lower as compared to male controls. LDL-Chol of female FDRs was 
      significantly lower than the female controls. No significant difference was 
      observed in the total cholesterol and the triglycerides level of the patients of 
      T2DM and FDRs but those cases in which pre-beta band appear upon lipoprotein 
      electrophoresis had significantly higher triglyceride levels as compared to those 
      patients in which pre-beta band did not appear. CONCLUSION: Lipoproteins of the 
      T2DM patients and FDRs group were found to be highly disturbed as compared to the 
      control group and they show a trend of developing atherogenic states in future.
FAU - Rukh, Gull
AU  - Rukh G
AD  - Department of Biochemistry & Chemical Pathology, SZ FPGMI Lahore, Pakistan.
FAU - Ali, Nasir
AU  - Ali N
FAU - Afzal, Naeema
AU  - Afzal N
FAU - Khan, Taher Salim
AU  - Khan TS
FAU - Shahjahan, S
AU  - Shahjahan S
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Ayub Med Coll Abbottabad
JT  - Journal of Ayub Medical College, Abbottabad : JAMC
JID - 8910750
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Atherosclerosis/etiology
MH  - Blood Glucose/metabolism
MH  - Case-Control Studies
MH  - Cholesterol/*blood
MH  - Diabetes Mellitus, Type 2/*blood/*genetics
MH  - *Family
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Triglycerides/*blood
EDAT- 2008/08/13 09:00
MHDA- 2008/10/10 09:00
CRDT- 2008/08/13 09:00
PHST- 2008/08/13 09:00 [pubmed]
PHST- 2008/10/10 09:00 [medline]
PHST- 2008/08/13 09:00 [entrez]
PST - ppublish
SO  - J Ayub Med Coll Abbottabad. 2007 Oct-Dec;19(4):89-93.