PMID- 18693614 OWN - NLM STAT- MEDLINE DCOM- 20081009 LR - 20080812 IS - 1025-9589 (Print) IS - 1025-9589 (Linking) VI - 19 IP - 4 DP - 2007 Oct-Dec TI - Large B cell lymphoma--year by year. PG - 121-6 AB - Non Hodgkin's Lymphoma (NHL) comprises a group of lymphoproliferative disorders the frequency of which continues to rise. Although many classification systems exist for identifying specific histological subtypes, NHL is generally divided into indolent (low-grade) and aggressive (intermediate- and high-grade) forms. Large B Cell Lymphoma (LBCL) is one of the commonest aggressive NHLs. The aim of this review is to provide a general overview of NHL, its clinically practicable cellular classification, epidemiology and in depth overview of the evolution of treatment of LBCL during the past 5 years. Current guidelines from National Cancer Institute (NCI), USA and National Institute on Clinical Excellence (NICE), UK are mentioned and recommendations according to our own set-up are suggested. FAU - Syed, Abdus Samad AU - Syed AS AD - Department of Oncology, Combined Military Hospital, Rawalpindi, Pakistan. FAU - Samad, Fauzia Abdus AU - Samad FA FAU - ur Rahman, Mahmood AU - ur Rahman M LA - eng PT - Journal Article PT - Review PL - Pakistan TA - J Ayub Med Coll Abbottabad JT - Journal of Ayub Medical College, Abbottabad : JAMC JID - 8910750 SB - IM MH - Humans MH - *Lymphoma, Large B-Cell, Diffuse/diagnosis/epidemiology/therapy RF - 45 EDAT- 2008/08/13 09:00 MHDA- 2008/10/10 09:00 CRDT- 2008/08/13 09:00 PHST- 2008/08/13 09:00 [pubmed] PHST- 2008/10/10 09:00 [medline] PHST- 2008/08/13 09:00 [entrez] PST - ppublish SO - J Ayub Med Coll Abbottabad. 2007 Oct-Dec;19(4):121-6.