PMID- 18694739
OWN - NLM
STAT- MEDLINE
DCOM- 20081216
LR  - 20151119
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1233
DP  - 2008 Oct 3
TI  - Cytokine-induced neutrophil chemoattractant (CINC)-1 induces fever by a 
      prostaglandin-dependent mechanism in rats.
PG  - 79-88
LID - 10.1016/j.brainres.2008.07.069 [doi]
AB  - Cytokine-induced neutrophil chemoattractant-1 (CINC-1), a member of the ELR+CXC 
      subfamily [ELR motif (glutamic acid-leucine-arginine) adjacent to the 
      cysteine-X-cysteine (CXC) motif located at the N-terminus of the protein], is an 
      acute-phase protein and its synthesis is induced by endogenous and exogenous 
      pyrogens. However, there are no studies on the pyrogenic property of CINC-1. 
      Therefore, the present study evaluates whether centrally administered CINC-1 
      promotes an integrated febrile response along with an increase in the 
      prostaglandin (PG)E2 content of the cerebrospinal fluid (CSF) of rats. The 
      effects of antipyretic drugs on fever and on the PGE2 content of the CSF as well 
      as the effectiveness of a neutralizing anti-CINC-1 antibody on the fever induced 
      by CINC-1 have also been investigated. Intracerebroventricular (i.c.v.) injection 
      of CINC-1 induced a dose-dependent bell-shaped rise on body temperature and 
      increased PGE2 concentration in the CSF of conscious rats. Injected into the 
      preoptic area of the anterior hypothalamus (AH/POA) (i.h.), CINC-1 also induced a 
      dose-dependent bell-shaped increase in body temperature along with a decrease on 
      tail skin temperature. Indomethacin (INDO, 2 mg kg(-1), i.p.) and ibuprofen (IBU, 
      10 mg kg(-1), i.p.) markedly reduced the fever evoked by i.c.v. injection of 
      CINC-1 (25 ng/site). Orally given celecoxib (5 mg kg(-1), 30 min. before) 
      abolished the fever induced by CINC-1 i.c.v. or i.h. (50 pg) injection. The 
      antipyretic drugs also blocked the PGE(2) increase after CINC-1 i.c.v. injection. 
      Co-injected anti-CINC antibody (10 ng/site) strongly reduced the febrile response 
      induced by CINC-1 (50 pg/site) injected intrahypothalamically. This is the first 
      time that centrally injected CINC-1 has been reported to act directly on the 
      pyrogen-sensitive neurons of AH/POA, promoting a thermoregulatory response that 
      seems to depend on other endogenous pyrogens synthesis and, as seen here, on 
      PGE2.
FAU - Soares, Denis Melo
AU  - Soares DM
AD  - Laboratory of Pharmacology, Department of Physics and Chemistry, Faculty of 
      Pharmaceutical Sciences, USP, Ribeirao Preto, SP, Brazil.
FAU - Machado, Renes R
AU  - Machado RR
FAU - Yamashiro, Livia H
AU  - Yamashiro LH
FAU - Melo, Miriam C C
AU  - Melo MC
FAU - Souza, Gloria E P
AU  - Souza GE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080729
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Chemokine CXCL1)
RN  - 0 (Cxcl1 protein, rat)
RN  - 0 (Pyrazoles)
RN  - 0 (Sulfonamides)
RN  - JCX84Q7J1L (Celecoxib)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/pharmacology
MH  - Body Temperature/physiology
MH  - Celecoxib
MH  - Chemokine CXCL1/administration & dosage/drug effects/*physiology
MH  - Dinoprostone/*cerebrospinal fluid
MH  - Dose-Response Relationship, Drug
MH  - Fever/drug therapy/*metabolism
MH  - Injections, Intraventricular
MH  - Male
MH  - Preoptic Area/*metabolism
MH  - Pyrazoles/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Statistics, Nonparametric
MH  - Sulfonamides/pharmacology
EDAT- 2008/08/13 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/08/13 09:00
PHST- 2008/01/28 00:00 [received]
PHST- 2008/07/11 00:00 [revised]
PHST- 2008/07/11 00:00 [accepted]
PHST- 2008/08/13 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/08/13 09:00 [entrez]
AID - S0006-8993(08)01753-8 [pii]
AID - 10.1016/j.brainres.2008.07.069 [doi]
PST - ppublish
SO  - Brain Res. 2008 Oct 3;1233:79-88. doi: 10.1016/j.brainres.2008.07.069. Epub 2008 
      Jul 29.