PMID- 18695980
OWN - NLM
STAT- MEDLINE
DCOM- 20090130
LR  - 20211020
IS  - 1432-1041 (Electronic)
IS  - 0031-6970 (Linking)
VI  - 64
IP  - 12
DP  - 2008 Dec
TI  - A clinical evaluation of the Janus Web Application, a software screening tool for 
      drug-drug interactions.
PG  - 1209-14
LID - 10.1007/s00228-008-0547-x [doi]
AB  - PURPOSE: To evaluate the clinical relevance of the Janus Web Application (JWA) in 
      screening for potential drug-drug interactions (DDIs). METHODS: One hundred and 
      fifty patients taking two drugs or more were studied. Potential DDIs were 
      identified by the JWA. Interviewing the patient and looking into his/her medical 
      records provided complementing information. A clinical pharmacologist judged 
      which potential DDIs were clinically relevant. Potentially relevant DDIs 
      identified by the JWA were then correlated with clinically relevant DDIs. 
      RESULTS: A total of 150 significant potential DDIs were found. Sixteen percent 
      (24/150) were judged to be clinically relevant. CONCLUSIONS: A very small 
      proportion of DDIs was considered clinically relevant in the specific clinical 
      context. To optimise the software's user-friendliness, the following points need 
      to be considered: the possibility of eliminating trivial potential DDIs, 
      individualising drug alerts, and providing written information, accessible via a 
      hyperlink.
FAU - Mannheimer, Buster
AU  - Mannheimer B
AD  - Department of Internal Medicine, Karolinska Institutet, Sodersjukhuset, SE-11883, 
      Stockholm, Sweden. buster.mannheimer@sodersjukhuset.se
FAU - Ulfvarson, Johanna
AU  - Ulfvarson J
FAU - Eklof, Sara
AU  - Eklof S
FAU - Bergqvist, Monica
AU  - Bergqvist M
FAU - von Bahr, Christer
AU  - von Bahr C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080810
PL  - Germany
TA  - Eur J Clin Pharmacol
JT  - European journal of clinical pharmacology
JID - 1256165
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Aged
MH  - *Decision Support Systems, Clinical
MH  - *Drug Interactions
MH  - *Drug Utilization Review/methods/statistics & numerical data
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Female
MH  - Humans
MH  - Male
MH  - Medical Records
MH  - *Pharmaceutical Preparations/administration & dosage
MH  - *Software
MH  - Surveys and Questionnaires
MH  - Sweden
EDAT- 2008/08/13 09:00
MHDA- 2009/01/31 09:00
CRDT- 2008/08/13 09:00
PHST- 2008/04/30 00:00 [received]
PHST- 2008/07/17 00:00 [accepted]
PHST- 2008/08/13 09:00 [pubmed]
PHST- 2009/01/31 09:00 [medline]
PHST- 2008/08/13 09:00 [entrez]
AID - 10.1007/s00228-008-0547-x [doi]
PST - ppublish
SO  - Eur J Clin Pharmacol. 2008 Dec;64(12):1209-14. doi: 10.1007/s00228-008-0547-x. 
      Epub 2008 Aug 10.