PMID- 18697487
OWN - NLM
STAT- MEDLINE
DCOM- 20081002
LR  - 20190823
IS  - 0387-5911 (Print)
IS  - 0387-5911 (Linking)
VI  - 82
IP  - 4
DP  - 2008 Jul
TI  - [AIDS-related Mycobacterium avium infection dissemination in a patient with 
      endobronchial lesions associated with immune reconstitution inflammatory 
      syndrome].
PG  - 341-6
AB  - Highly active antiretroviral therapy (HAART) has dramatically decreased the 
      incidence of HIV-1-associated morbidity and mortality. During the initial months 
      of HAART, immune reconstitution inflammatory syndrome (IRIS), an adverse 
      consequence of restoration of the pathogen-specific immune response, often 
      occurred in terminal-stage in patients, with MAC infection the most frequently 
      implicated in IRIS. In August 2004, a 26-year-old Japanese woman with fever and 
      general lymphadenopathy was diagnosed with AIDS (HIV-1 RNA 5.7 x 10(5) copies/mL, 
      CD4+ T cell count 10/microL) and disseminated Mycobacterium avium (M. avium) 
      infection, for which antimycobacterial treatment was initiated. The M. avium 
      infection responded well to two months of this treatment, and HAART was begun. 
      Despite good virologic response to HAART (HIV-1 RNA <50 copies/mL), she 
      contracted pulmonary disease with parenchymal lung changes, endobronchial 
      lesions, and localized supraclavicular lymphadenitis, which are M. 
      avium-associated IRIS. Good immunological response (CD4+ T cell count 136/microL) 
      and a stronger antimycobacterial treatment helped her overcoming M. 
      avium-associated IRIS without systemic corticosteroids or the discontinuation of 
      HAART. The possibility of IRIS should always be watched for when treating AIDS 
      patients with HAART and an antimycobacterial treatment regimen formulated that 
      considers potential drug interactions with HAART.
FAU - Ogawa, Eiichi
AU  - Ogawa E
AD  - Department of General Medicine, Kyushu University Hospital.
FAU - Murata, Masayuki
AU  - Murata M
FAU - Ohnishi, Hachirou
AU  - Ohnishi H
FAU - Tatsukawa, Masafumi
AU  - Tatsukawa M
FAU - Sawayama, Yasunori
AU  - Sawayama Y
FAU - Furusyo, Norihiro
AU  - Furusyo N
FAU - Hayashi, Jun
AU  - Hayashi J
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Kansenshogaku Zasshi
JT  - Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious 
      Diseases
JID - 0236671
RN  - 0 (Anti-Bacterial Agents)
RN  - H1250JIK0A (Clarithromycin)
RN  - Y45QSO73OB (Streptomycin)
SB  - IM
MH  - *AIDS-Related Opportunistic Infections
MH  - Acquired Immunodeficiency Syndrome/*complications/*drug therapy
MH  - Adult
MH  - Anti-Bacterial Agents/administration & dosage
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Bronchial Diseases/*etiology
MH  - Bronchitis/*drug therapy/*microbiology
MH  - Clarithromycin/administration & dosage
MH  - Female
MH  - HIV-1
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/drug therapy/*etiology
MH  - *Mycobacterium avium-intracellulare Infection
MH  - Streptomycin/administration & dosage
MH  - Treatment Outcome
EDAT- 2008/08/14 09:00
MHDA- 2008/10/03 09:00
CRDT- 2008/08/14 09:00
PHST- 2008/08/14 09:00 [pubmed]
PHST- 2008/10/03 09:00 [medline]
PHST- 2008/08/14 09:00 [entrez]
AID - 10.11150/kansenshogakuzasshi1970.82.341 [doi]
PST - ppublish
SO  - Kansenshogaku Zasshi. 2008 Jul;82(4):341-6. doi: 
      10.11150/kansenshogakuzasshi1970.82.341.