PMID- 18697552
OWN - NLM
STAT- MEDLINE
DCOM- 20080915
LR  - 20211020
IS  - 0094-2405 (Print)
IS  - 0094-2405 (Electronic)
IS  - 0094-2405 (Linking)
VI  - 35
IP  - 7
DP  - 2008 Jul
TI  - Integration of SimSET photon history generator in GATE for efficient Monte Carlo 
      simulations of pinhole SPECT.
PG  - 3278-84
AB  - The authors developed and validated an efficient Monte Carlo simulation (MCS) 
      workflow to facilitate small animal pinhole SPECT imaging research. This workflow 
      seamlessly integrates two existing MCS tools: simulation system for emission 
      tomography (SimSET) and GEANT4 application for emission tomography (GATE). 
      Specifically, we retained the strength of GATE in describing complex 
      collimator/detector configurations to meet the anticipated needs for studying 
      advanced pinhole collimation (e.g., multipinhole) geometry, while inserting the 
      fast SimSET photon history generator (PHG) to circumvent the relatively slow 
      GEANT4 MCS code used by GATE in simulating photon interactions inside voxelized 
      phantoms. For validation, data generated from this new SimSET-GATE workflow were 
      compared with those from GATE-only simulations as well as experimental 
      measurements obtained using a commercial small animal pinhole SPECT system. Our 
      results showed excellent agreement (e.g., in system point response functions and 
      energy spectra) between SimSET-GATE and GATE-only simulations, and, more 
      importantly, a significant computational speedup (up to approximately 10-fold) 
      provided by the new workflow. Satisfactory agreement between MCS results and 
      experimental data were also observed. In conclusion, the authors have 
      successfully integrated SimSET photon history generator in GATE for fast and 
      realistic pinhole SPECT simulations, which can facilitate research in, for 
      example, the development and application of quantitative pinhole and multipinhole 
      SPECT for small animal imaging. This integrated simulation tool can also be 
      adapted for studying other preclinical and clinical SPECT techniques.
FAU - Chen, Chia-Lin
AU  - Chen CL
AD  - Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming 
      University, Taipei 102, Taiwan.
FAU - Wang, Yuchuan
AU  - Wang Y
FAU - Lee, Jason J S
AU  - Lee JJ
FAU - Tsui, Benjamin M W
AU  - Tsui BM
LA  - eng
GR  - EB168/EB/NIBIB NIH HHS/United States
GR  - R24 CA092871/CA/NCI NIH HHS/United States
GR  - R01 EB001558/EB/NIBIB NIH HHS/United States
GR  - EB1558/EB/NIBIB NIH HHS/United States
GR  - CA92871/CA/NCI NIH HHS/United States
GR  - U24 CA092871/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Phys
JT  - Medical physics
JID - 0425746
SB  - IM
MH  - Algorithms
MH  - Animals
MH  - Computer Simulation
MH  - Computers
MH  - Equipment Design
MH  - Image Processing, Computer-Assisted
MH  - Monte Carlo Method
MH  - Phantoms, Imaging
MH  - *Photons
MH  - Positron-Emission Tomography/methods
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Software
MH  - Tomography, Emission-Computed, Single-Photon/*instrumentation/*methods
PMC - PMC2809718
EDAT- 2008/08/14 09:00
MHDA- 2008/09/16 09:00
PMCR- 2009/07/01
CRDT- 2008/08/14 09:00
PHST- 2008/08/14 09:00 [pubmed]
PHST- 2008/09/16 09:00 [medline]
PHST- 2008/08/14 09:00 [entrez]
PHST- 2009/07/01 00:00 [pmc-release]
AID - 034807MPH [pii]
AID - 10.1118/1.2940159 [doi]
PST - ppublish
SO  - Med Phys. 2008 Jul;35(7):3278-84. doi: 10.1118/1.2940159.