PMID- 18699966
OWN - NLM
STAT- MEDLINE
DCOM- 20080904
LR  - 20211020
IS  - 1365-2184 (Electronic)
IS  - 0960-7722 (Print)
IS  - 0960-7722 (Linking)
VI  - 41
IP  - 4
DP  - 2008 Aug
TI  - Exogenous bone marrow cells do not rescue non-irradiated mice from acute renal 
      tubular damage caused by HgCl2, despite establishment of chimaerism and cell 
      proliferation in bone marrow and spleen.
PG  - 592-606
LID - 10.1111/j.1365-2184.2008.00546.x [doi]
AB  - OBJECTIVE: Various studies have shown that bone marrow stem cells can rescue mice 
      from acute renal tubular damage under a conditioning advantage (irradiation or 
      cisplatin treatment) favouring donor cell engraftment and regeneration; however, 
      it is not known whether bone marrow cells (BMCs) can contribute to repair of 
      acute tubular damage in the absence of a selection pressure for the donor cells. 
      The aim of this study was to examine this possibility. MATERIALS AND METHODS: 
      Ten-week-old female mice were assigned into control non-irradiated animals having 
      only vehicle treatment, HgCl(2)-treated non-irradiated mice, HgCl(2)-treated 
      non-irradiated mice infused with male BMCs 1 day after HgCl(2), and 
      vehicle-treated mice with male BMCs. Tritiated thymidine was given 1 h before 
      animal killing. RESULTS: Donor BMCs could not alleviate non-irradiated mice from 
      acute tubular damage caused by HgCl(2), deduced by no reduction in serum urea 
      nitrogen combined with negligible cell engraftment. However, donor BMCs could 
      home to the bone marrow and spleen and display proliferative activity. This is 
      the first report to show that despite no preparative myeloablation of recipients, 
      engrafted donor BMCs can synthesize DNA in the bone marrow and spleen. 
      CONCLUSIONS: Exogenous BMCs do not rescue non-irradiated mice from acute renal 
      tubular damage caused by HgCl(2), despite establishment of chimerism and cell 
      proliferation in bone marrow and spleen.
FAU - Fang, T-C
AU  - Fang TC
AD  - Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. 
      fangtechao@yahoo.com.tw
FAU - Otto, W R
AU  - Otto WR
FAU - Jeffery, R
AU  - Jeffery R
FAU - Hunt, T
AU  - Hunt T
FAU - Alison, M R
AU  - Alison MR
FAU - Cook, H T
AU  - Cook HT
FAU - Wright, N A
AU  - Wright NA
FAU - Poulsom, R
AU  - Poulsom R
LA  - eng
GR  - Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cell Prolif
JT  - Cell proliferation
JID - 9105195
RN  - 53GH7MZT1R (Mercuric Chloride)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/*cytology/drug effects/pathology/*physiology
MH  - *Bone Marrow Transplantation
MH  - Cell Division
MH  - Kidney Tubules/drug effects/*pathology
MH  - Mercuric Chloride/*toxicity
MH  - Mice
MH  - Spleen/*cytology/drug effects/pathology
MH  - *Transplantation Chimera
PMC - PMC6495886
EDAT- 2008/08/14 09:00
MHDA- 2008/09/05 09:00
PMCR- 2008/07/08
CRDT- 2008/08/14 09:00
PHST- 2008/08/14 09:00 [pubmed]
PHST- 2008/09/05 09:00 [medline]
PHST- 2008/08/14 09:00 [entrez]
PHST- 2008/07/08 00:00 [pmc-release]
AID - CPR546 [pii]
AID - 10.1111/j.1365-2184.2008.00546.x [doi]
PST - ppublish
SO  - Cell Prolif. 2008 Aug;41(4):592-606. doi: 10.1111/j.1365-2184.2008.00546.x.