PMID- 18700138
OWN - NLM
STAT- MEDLINE
DCOM- 20081118
LR  - 20131121
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 595
IP  - 1-3
DP  - 2008 Oct 24
TI  - Brain-derived neurotrophic factor enhances histamine-induced airway responses and 
      changes levels of exhaled nitric oxide in guinea pigs in vivo.
PG  - 78-83
LID - 10.1016/j.ejphar.2008.07.041 [doi]
AB  - The neurotrophin brain-derived neurotrophic factor (BDNF) occurs in elevated 
      levels during airway inflammation, including asthma and hypoxic lung injury, and 
      has been suggested to be associated with airway hyperresponsiveness in these 
      conditions. The aim of the present study was to examine whether airway responses 
      to histamine challenge and levels of exhaled nitric oxide (NO) in vivo might be 
      altered upon BDNF treatment. Pulmonary resistance, lung compliance, insufflation 
      pressure, and levels of exhaled NO were measured in anaesthetized guinea pigs 
      exposed to BDNF prior to challenge with histamine and with intact or inhibited 
      endogenous NO production. BDNF pretreatment significantly enhanced 
      histamine-evoked increase in pulmonary resistance and insufflation pressure, as 
      well as the decrease in lung compliance. BDNF markedly accentuated the reduction 
      in exhaled NO following histamine challenge. In animals with inhibited endogenous 
      NO production BDNF induced a significantly earlier histamine-evoked increase in 
      airway responses. The present data show that BDNF can induce an augmentation of 
      histamine-evoked airway responses and reduce levels of NO in exhaled air in vivo. 
      Endogenous NO seems to exert a braking action on BDNF-induced enhancement of 
      airway responses and a reduced ability to release NO may be one mechanism for 
      increased airway response during elevated BDNF levels. Taken together this 
      indicates that BDNF may be of importance for airway hyperresponsiveness in vivo. 
      The interaction between BDNF and airway NO formation, and its relation to airway 
      responses, merit further investigation.
FAU - Bennedich Kahn, Lydia
AU  - Bennedich Kahn L
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 
      Sweden. Lydia.Bennedich@ki.se
FAU - Gustafsson, Lars E
AU  - Gustafsson LE
FAU - Olgart Hoglund, Caroline
AU  - Olgart Hoglund C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080730
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Bronchoconstrictor Agents)
RN  - 0 (Enzyme Inhibitors)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 820484N8I3 (Histamine)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Administration, Inhalation
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/administration & dosage/*metabolism
MH  - Bronchial Hyperreactivity/metabolism/physiopathology
MH  - Bronchoconstriction/*drug effects
MH  - Bronchoconstrictor Agents/*administration & dosage
MH  - Disease Models, Animal
MH  - Enzyme Inhibitors/pharmacology
MH  - *Exhalation
MH  - Guinea Pigs
MH  - Histamine/*administration & dosage
MH  - Infusions, Intravenous
MH  - Injections, Intravenous
MH  - Lung/blood supply/*drug effects/metabolism/physiopathology
MH  - Lung Compliance/drug effects
MH  - Male
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Nitric Oxide/*metabolism
MH  - Nitric Oxide Synthase/antagonists & inhibitors/metabolism
MH  - Pressure
MH  - Time Factors
MH  - Vascular Resistance/drug effects
EDAT- 2008/08/14 09:00
MHDA- 2008/11/19 09:00
CRDT- 2008/08/14 09:00
PHST- 2008/06/14 00:00 [received]
PHST- 2008/07/16 00:00 [revised]
PHST- 2008/07/23 00:00 [accepted]
PHST- 2008/08/14 09:00 [pubmed]
PHST- 2008/11/19 09:00 [medline]
PHST- 2008/08/14 09:00 [entrez]
AID - S0014-2999(08)00797-8 [pii]
AID - 10.1016/j.ejphar.2008.07.041 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2008 Oct 24;595(1-3):78-83. doi: 10.1016/j.ejphar.2008.07.041. 
      Epub 2008 Jul 30.