PMID- 18700875
OWN - NLM
STAT- MEDLINE
DCOM- 20090518
LR  - 20111117
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 72
IP  - 4
DP  - 2008 Oct
TI  - Re-evaluation of heterogeneity in HLA-B*510101 associated with Behcet's disease.
PG  - 347-53
LID - 10.1111/j.1399-0039.2008.01111.x [doi]
AB  - Behcet's disease (BD) is a chronic inflammatory disease characterized by oral 
      aphthous ulcers, genital ulcers, uveitis and skin lesions. Etiology and 
      pathogenesis of BD are not fully elucidated, but the association with human 
      leukocyte antigen (HLA)-B51 or B*5101 has been repeatedly reported. Previous 
      studies have shown that there are few sequence variations in the protein-coding 
      region of B51, while there is a report on many variations in the 5'-flanking 
      region and intron. In this study, HLA-B*5101 gene from 37 individuals including 
      Japanese, Turkish, Jordanian and Iranian patients and healthy controls were fully 
      sequenced to further clarify the B*5101 gene in association with BD. We found 
      that all the patients and healthy controls carried B*510101 with no variation in 
      the 5'-flanking region, exon and intron. However, seven polymorphisms were found 
      in the 3'-flanking region. These polymorphisms composed of six haplotypes that 
      were shared and stretched over the ethnic groups, suggesting that the 
      susceptibility to BD was conferred by the B*510101 itself and not by any genes in 
      linkage disequilibrium with B*510101. In addition, phylogenetic analyses of 
      B*510101 showed that the 3'-flanking sequences followed an evolutional divergence 
      differently from that of the other regions, implying that a unifying selection 
      might operate to conserve B*510101.
FAU - Takemoto, Y
AU  - Takemoto Y
AD  - Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate 
      School of Medicine, Sapporo, Japan.
FAU - Naruse, T
AU  - Naruse T
FAU - Namba, K
AU  - Namba K
FAU - Kitaichi, N
AU  - Kitaichi N
FAU - Ota, M
AU  - Ota M
FAU - Shindo, Y
AU  - Shindo Y
FAU - Mizuki, N
AU  - Mizuki N
FAU - Gul, A
AU  - Gul A
FAU - Madanat, W
AU  - Madanat W
FAU - Chams, H
AU  - Chams H
FAU - Davatchi, F
AU  - Davatchi F
FAU - Inoko, H
AU  - Inoko H
FAU - Ohno, S
AU  - Ohno S
FAU - Kimura, A
AU  - Kimura A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080812
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B51 Antigen)
SB  - IM
MH  - Base Sequence
MH  - Behcet Syndrome/*genetics
MH  - Exons
MH  - Genetic Predisposition to Disease
MH  - HLA-B Antigens/*genetics
MH  - HLA-B51 Antigen
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Introns
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Polymorphism, Genetic
EDAT- 2008/08/15 09:00
MHDA- 2009/05/19 09:00
CRDT- 2008/08/15 09:00
PHST- 2008/08/15 09:00 [pubmed]
PHST- 2009/05/19 09:00 [medline]
PHST- 2008/08/15 09:00 [entrez]
AID - TAN1111 [pii]
AID - 10.1111/j.1399-0039.2008.01111.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Oct;72(4):347-53. doi: 10.1111/j.1399-0039.2008.01111.x. 
      Epub 2008 Aug 12.