PMID- 18700879
OWN - NLM
STAT- MEDLINE
DCOM- 20090518
LR  - 20211020
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 72
IP  - 4
DP  - 2008 Oct
TI  - Tumor escape mechanisms: potential role of soluble HLA antigens and NK cells 
      activating ligands.
PG  - 321-34
LID - 10.1111/j.1399-0039.2008.01106.x [doi]
AB  - The crucial role played by human leukocyte antigen (HLA) antigens and natural 
      killer (NK)-cell-activating ligands in the interactions of malignant cells with 
      components of the host's immune system has stimulated interest in the 
      characterization of their expression by malignant cells. Convincing evidence 
      generated by the immunohistochemical staining of surgically removed malignant 
      lesions with monoclonal antibodies recognizing HLA antigens and 
      NK-cell-activating ligands indicates that the surface expression of these 
      molecules is frequently altered on malignant cells. These changes appear to have 
      clinical significance because in some types of malignant disease they are 
      associated with the histopathological characteristics of the lesions as well as 
      with disease-free interval and survival. These associations have been suggested 
      to reflect the effect of HLA antigen and NK-cell-activating ligand abnormalities 
      on the interactions of tumor cells with antigen-specific cytotoxic T lymphocytes 
      (CTL) and with NK cells. Nevertheless, there are examples in which disease 
      progresses in the face of appropriate HLA antigen and/or NK-cell-activating 
      ligand as well as tumor antigen expression by malignant cells and of functional 
      antigen-specific CTL in the investigated patient. In such scenarios, it is likely 
      that the tumor microenvironment is unfavorable for CTL and NK cell activity and 
      contributes to tumor immune escape. Many distinct escape mechanisms have been 
      shown to protect malignant cells from immune recognition and destruction in the 
      tumor microenvironment. In this article, following the description of the 
      structural and functional characteristics of soluble HLA antigens and 
      NK-cell-activating ligands, we will review changes in their serum level in 
      malignant disease and discuss their potential role in the escape mechanisms used 
      by tumor cells to avoid recognition and destruction.
FAU - Campoli, M
AU  - Campoli M
AD  - Department of Dermatology, University of Colorado Health Science Center, Denver, 
      CO, USA.
FAU - Ferrone, S
AU  - Ferrone S
LA  - eng
GR  - R01 CA110249/CA/NCI NIH HHS/United States
GR  - R01 CA110249-03/CA/NCI NIH HHS/United States
GR  - R01CA110249/CA/NCI NIH HHS/United States
GR  - P01CA109688/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20080812
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (Ligands)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/immunology/metabolism
MH  - CD8-Positive T-Lymphocytes/immunology/metabolism
MH  - Cytotoxicity, Immunologic/*immunology
MH  - HLA Antigens/*blood/immunology
MH  - Humans
MH  - Killer Cells, Natural/*immunology/metabolism
MH  - Ligands
MH  - Neoplasms/*immunology
MH  - Tumor Escape/*immunology
PMC - PMC2729103
MID - NIHMS131324
EDAT- 2008/08/15 09:00
MHDA- 2009/05/19 09:00
PMCR- 2009/08/19
CRDT- 2008/08/15 09:00
PHST- 2008/08/15 09:00 [pubmed]
PHST- 2009/05/19 09:00 [medline]
PHST- 2008/08/15 09:00 [entrez]
PHST- 2009/08/19 00:00 [pmc-release]
AID - TAN1106 [pii]
AID - 10.1111/j.1399-0039.2008.01106.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Oct;72(4):321-34. doi: 10.1111/j.1399-0039.2008.01106.x. 
      Epub 2008 Aug 12.