PMID- 18701059 OWN - NLM STAT- MEDLINE DCOM- 20080917 LR - 20091119 IS - 1097-4199 (Electronic) IS - 0896-6273 (Linking) VI - 59 IP - 3 DP - 2008 Aug 14 TI - Keeping 'trk' of antidepressant actions. PG - 349-51 LID - 10.1016/j.neuron.2008.07.028 [doi] AB - Despite growing evidence that increased brain-derived neurotrophic factor (BDNF) and hippocampal adult neurogenesis are necessary for the behavioral actions of antidepressants in rodents, the cellular mechanisms involved in these effects are still unknown. Li et al. in this issue of Neuron demonstrate that the presence of TrkB, the high-affinity receptor for BDNF, in hippocampal neural progenitor cells is required for the neurogenic and behavioral actions of antidepressant treatments. FAU - Banasr, Mounira AU - Banasr M AD - Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA. FAU - Duman, Ronald S AU - Duman RS LA - eng PT - Comment PT - Journal Article PL - United States TA - Neuron JT - Neuron JID - 8809320 RN - 0 (Antidepressive Agents) RN - EC 2.7.10.1 (Receptor, trkB) SB - IM CON - Neuron. 2008 Aug 14;59(3):399-412. PMID: 18701066 MH - Adult Stem Cells/drug effects MH - Animals MH - Antidepressive Agents/*pharmacology MH - Cell Proliferation/*drug effects MH - Mice MH - Neurons/drug effects MH - Receptor, trkB/*metabolism EDAT- 2008/08/15 09:00 MHDA- 2008/09/18 09:00 CRDT- 2008/08/15 09:00 PHST- 2008/08/15 09:00 [pubmed] PHST- 2008/09/18 09:00 [medline] PHST- 2008/08/15 09:00 [entrez] AID - S0896-6273(08)00627-2 [pii] AID - 10.1016/j.neuron.2008.07.028 [doi] PST - ppublish SO - Neuron. 2008 Aug 14;59(3):349-51. doi: 10.1016/j.neuron.2008.07.028.