PMID- 18702298
OWN - NLM
STAT- MEDLINE
DCOM- 20080923
LR  - 20110719
IS  - 0026-8984 (Print)
IS  - 0026-8984 (Linking)
VI  - 42
IP  - 3
DP  - 2008 May-Jun
TI  - [Transcription factors of the nuclear factor 1 (NF1) family. Role in chromatin 
      remodelation].
PG  - 388-404
AB  - Site-specific transcription factors of the nuclear factor 1 (NF1) family are 
      ubiquitous, are encoded by four genes in mammals, and play a role in regulating 
      transcription of approximately 100 cell and viral genes. The NF1 proteins are 
      characterized by the ability to act as both transcription factors and viral 
      replication factors and by a low affinity for nucleosomal DNA. The review 
      considers the dual role of the NF1 family factors in hormone-mediated 
      transactivation of mouse mammary tumor virus (MMTV) promoter: the factors are 
      essential for both transcription activation and nucleosome remodeling. Emphasis 
      is placed on the role of the NF1 family factors in the formation and maintenance 
      of a preset chromatin structure in the MMTV promoter region and the regulatory 
      elements of the lysozyme gene during macrophage differentiation. Since disruption 
      of individual NF1 family genes caused pathological changes in human and animal 
      tissues, the NF1 family proteins are subjects of basic and applied research.
FAU - Chikhirzhina, G I
AU  - Chikhirzhina GI
FAU - Al'-Shekhadat, R I
AU  - Al'-Shekhadat RI
FAU - Chikhirzhina, E V
AU  - Chikhirzhina EV
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Russia (Federation)
TA  - Mol Biol (Mosk)
JT  - Molekuliarnaia biologiia
JID - 0105454
RN  - 0 (NFI Transcription Factors)
RN  - 0 (Nucleosomes)
SB  - IM
MH  - Animals
MH  - Chromatin Assembly and Disassembly/*physiology
MH  - Humans
MH  - Mammary Tumor Virus, Mouse/physiology
MH  - Mice
MH  - NFI Transcription Factors/*genetics/*metabolism
MH  - Nucleosomes/*genetics/*metabolism
MH  - Promoter Regions, Genetic/physiology
MH  - Transcription, Genetic/*physiology
MH  - Transcriptional Activation/physiology
MH  - Virus Replication/physiology
RF  - 91
EDAT- 2008/08/16 09:00
MHDA- 2008/09/24 09:00
CRDT- 2008/08/16 09:00
PHST- 2008/08/16 09:00 [pubmed]
PHST- 2008/09/24 09:00 [medline]
PHST- 2008/08/16 09:00 [entrez]
PST - ppublish
SO  - Mol Biol (Mosk). 2008 May-Jun;42(3):388-404.