PMID- 18702953
OWN - NLM
STAT- MEDLINE
DCOM- 20080916
LR  - 20221207
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 57
IP  - 9
DP  - 2008 Sep
TI  - Determinants of postprandial triglyceride and glucose responses after two 
      consecutive fat-rich or carbohydrate-rich meals in normoglycemic women and in 
      women with type 2 diabetes mellitus: the Hoorn Prandial Study.
PG  - 1262-9
LID - 10.1016/j.metabol.2008.04.022 [doi]
AB  - Both postprandial hyperglycemia and hypertriglyceridemia have been identified as 
      risk markers for cardiovascular disease, but parameters associated with these 
      postprandial responses are largely unknown. The objective was to assess whether 
      usually measured clinical and biochemical parameters can predict postprandial 
      glucose and triglyceride responses and whether these responses are associated 
      with each other. Postmenopausal women, 76 with normal glucose metabolism (NGM) 
      and 41 with type 2 diabetes mellitus (T2DM), received 2 consecutive fat-rich 
      meals and carbohydrate-rich meals on separate occasions. Blood samples were taken 
      before and at t = 1, 2, 4, 6, and 8 hours after breakfast; lunch was given at t = 
      4 hours. Regression analysis was performed with incremental area under the 
      postprandial triglyceride curve (triglyceride-iAUC) and glucose curve 
      (glucose-iAUC) after fat-rich and carbohydrate-rich meals, respectively. In women 
      with NGM, fasting triglycerides, hemoglobin A(1c), total cholesterol, and, 
      inversely, high-density lipoprotein cholesterol were independently associated 
      with triglyceride-iAUC; and age and fasting triglycerides were independently 
      associated with glucose-iAUC. In women with T2DM, fasting triglycerides were 
      independently associated with triglyceride-iAUC, whereas hemoglobin A(1c) and 
      fasting glucose were stronger than fasting triglycerides associated with 
      glucose-iAUC. Glucose-iAUC and triglyceride-iAUC were associated with each other 
      in women with T2DM, but not in those with NGM. The association between 
      glucose-iAUC and triglyceride-iAUC in women with T2DM and the association of 
      fasting triglycerides with both glucose-iAUC and triglyceride-iAUC in NGM and 
      T2DM suggest a common underlying mechanism for postprandial increments in glucose 
      and triglycerides, especially in T2DM. Commonly measured clinical and biochemical 
      parameters can only partly explain postprandial glucose and triglyceride 
      excursions.
FAU - Alssema, Marjan
AU  - Alssema M
AD  - EMGO Institute, VU University Medical Center, 1007 MB Amsterdam, The Netherlands. 
      m.alssema@vumc.nl
FAU - Schindhelm, Roger K
AU  - Schindhelm RK
FAU - Dekker, Jacqueline M
AU  - Dekker JM
FAU - Diamant, Michaela
AU  - Diamant M
FAU - Nijpels, Giel
AU  - Nijpels G
FAU - Teerlink, Tom
AU  - Teerlink T
FAU - Scheffer, Peter G
AU  - Scheffer PG
FAU - Kostense, Piet J
AU  - Kostense PJ
FAU - Heine, Robert J
AU  - Heine RJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Area Under Curve
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Dietary Fats/*administration & dosage
MH  - Fasting/blood
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Middle Aged
MH  - Postmenopause/blood
MH  - *Postprandial Period
MH  - Predictive Value of Tests
MH  - Triglycerides/*blood
EDAT- 2008/08/16 09:00
MHDA- 2008/09/17 09:00
CRDT- 2008/08/16 09:00
PHST- 2007/12/05 00:00 [received]
PHST- 2008/04/22 00:00 [accepted]
PHST- 2008/08/16 09:00 [pubmed]
PHST- 2008/09/17 09:00 [medline]
PHST- 2008/08/16 09:00 [entrez]
AID - S0026-0495(08)00153-4 [pii]
AID - 10.1016/j.metabol.2008.04.022 [doi]
PST - ppublish
SO  - Metabolism. 2008 Sep;57(9):1262-9. doi: 10.1016/j.metabol.2008.04.022.