PMID- 1870426
OWN - NLM
STAT- MEDLINE
DCOM- 19910913
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 40
IP  - 7
DP  - 1991 Jul
TI  - Tumor necrosis factor-alpha and anorexia--cause or effect?
PG  - 720-3
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a principal cytokine that may induce 
      weight loss in malignancies and certain chronic infections. Short-term caloric 
      deprivation has been found to facilitate in vitro TNF-alpha production, while 
      increased spontaneous production of TNF-alpha has been found in patients with 
      anorexia nervosa (AN). In the present work, we studied in vitro TNF-alpha 
      production in other types of chronic undernutrition and the changes in TNF-alpha 
      production during the refeeding of patients with AN. Undernutrition was evaluated 
      by calculating fat body mass (FBM) from skinfold measurements and lean body mass 
      (LBM) by total body potassium (TBK) counting. Spontaneous and induced TNF-alpha 
      production by peripheral blood mononuclear cells (PBMC) was studied in six 
      chronically malnourished patients with no intercurrent infections, seven patients 
      with AN, and 16 age-matched normal healthy subjects. Spontaneous TNF-alpha 
      production was in the normal range in the chronically undernourished subjects 
      (4.3 +/- 1.5 v 5.0 +/- 1.9 U/mL), but significantly increased in the seven 
      patients with AN (221 +/- 327 v 5.0 +/- 1.9 U/mL, P less than .0006). During 
      refeeding of patients with AN, TNF-alpha production decreased to the normal range 
      concomitantly with weight gain. We concluded that chronic undernutrition, in 
      general, is not always associated with increased TNF-alpha production and that it 
      still remains to be determined whether TNF-alpha plays a primary role in the 
      pathogenesis of AN.
FAU - Vaisman, N
AU  - Vaisman N
AD  - Clinical Nutrition Clinic, Kaplan Hospital, Rehovot, Israel.
FAU - Hahn, T
AU  - Hahn T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Anorexia/*etiology/metabolism/pathology
MH  - Child
MH  - Food
MH  - Humans
MH  - Nutrition Disorders/metabolism
MH  - Reference Values
MH  - Tumor Necrosis Factor-alpha/*physiology
MH  - Weight Loss
EDAT- 1991/07/01 00:00
MHDA- 1991/07/01 00:01
CRDT- 1991/07/01 00:00
PHST- 1991/07/01 00:00 [pubmed]
PHST- 1991/07/01 00:01 [medline]
PHST- 1991/07/01 00:00 [entrez]
AID - 0026-0495(91)90090-J [pii]
AID - 10.1016/0026-0495(91)90090-j [doi]
PST - ppublish
SO  - Metabolism. 1991 Jul;40(7):720-3. doi: 10.1016/0026-0495(91)90090-j.