PMID- 18704309
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20221207
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 28
IP  - 4
DP  - 2008 Aug
TI  - Distribution characteristics and linkage disequilibrium of TIM4 promoter 
      polymorphisms in asthma patients of Chinese Han population.
PG  - 447-50
LID - 10.1007/s11596-008-0416-y [doi]
AB  - To investigate the distribution characteristics and linkage disequilibrium of T 
      cell immunoglobulin domain and mucin domain protein 4 (TIM4) promoter 
      polymorphisms in asthma patients of Chinese Han population, the promoter region 
      of TIM4 was re-sequenced by PCR-sequencing, and linkage disequilibrium was 
      analyzed by SHEsis software. Four single nucleotide polymorphisms (SNPs) in the 
      promoter region of TIM4 were detected, including two new SNPs (at 
      positions-1609,-153) and two reported SNPs (rs6874202, rs6882076). The frequency 
      distribution of rs6882076 was different among different races (P<0.05). In 
      addition, linkage disequilibrium among the SNPs of the promoter region of TIM4 
      was found and GGTG was the predominant haplotype. There were four SNPs in the 
      promoter region of TIM4 in asthma patients of Chinese Han population, which were 
      in linkage disequilibrium.
FAU - Cai, Pengcheng
AU  - Cai P
AD  - Department of Clinical Laboratory, Union Hospital, Huazhong University of Science 
      and Technology, Wuhan 430022, China. cpccpc@sohu.com
FAU - Wu, Qiwen
AU  - Wu Q
FAU - Wang, Lin
AU  - Wang L
FAU - Xiong, Juan
AU  - Xiong J
FAU - Chen, Fenghua
AU  - Chen F
FAU - Hu, Lihua
AU  - Hu L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080815
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Membrane Proteins)
RN  - 0 (TIMD4 protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asian People/genetics
MH  - Asthma/*genetics
MH  - Base Sequence
MH  - Child
MH  - Child, Preschool
MH  - China/ethnology
MH  - Female
MH  - Haplotypes
MH  - Humans
MH  - *Linkage Disequilibrium
MH  - Male
MH  - Membrane Proteins/*genetics
MH  - Molecular Sequence Data
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Young Adult
EDAT- 2008/08/16 09:00
MHDA- 2013/02/12 06:00
CRDT- 2008/08/16 09:00
PHST- 2008/01/23 00:00 [received]
PHST- 2008/08/16 09:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
PHST- 2008/08/16 09:00 [entrez]
AID - 10.1007/s11596-008-0416-y [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2008 Aug;28(4):447-50. doi: 
      10.1007/s11596-008-0416-y. Epub 2008 Aug 15.