PMID- 1870450
OWN - NLM
STAT- MEDLINE
DCOM- 19910916
LR  - 20191028
IS  - 0934-8832 (Print)
IS  - 0934-8832 (Linking)
VI  - 11
IP  - 3
DP  - 1991 Jun
TI  - Effects of growth factors on mucosal scar fibroblasts in culture--a possible role 
      of growth factors in scar formation.
PG  - 190-6
AB  - Various growth factors are known to play important roles in wound healing, 
      especially in an early inflammatory phase. However, their roles in subsequent 
      scar formation phase are relatively unexplored. The aim of this study is to 
      investigate the mechanisms of regulation in scar formation by these factors. Scar 
      fibroblasts (SF) were obtained from immature scar tissue made at rat hard palate 
      1 month after excision and normal fibroblasts (NF) were obtained from the palatal 
      mucosa of untreated control animals. SF showed a longer doubling time, and 
      increased level of protein synthesis when compared to NF. Platelet-derived growth 
      factor (PDGF) and epidermal growth factor (EGF) stimulated [3H]-thymidine uptake 
      less effectively in SF than in NF. In both cells, transforming growth factor-beta 
      1 (TGF-beta 1) inhibited EGF-induced stimulation of [3H]-thymidine uptake, but 
      had no effects when it was added alone. TGF-beta 1 increased collagen synthesis 
      more effectively in SF than in NF. These data indicate that the growth factors 
      may play key roles in regulating proliferation and metabolic activity of 
      fibroblasts during scar formation.
FAU - Moriyama, K
AU  - Moriyama K
AD  - Second Department of Orthodontics, School of Dentistry, Tokyo Medical and Dental 
      University, Japan.
FAU - Shimokawa, H
AU  - Shimokawa H
FAU - Susami, T
AU  - Susami T
FAU - Sasaki, S
AU  - Sasaki S
FAU - Kuroda, T
AU  - Kuroda T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Matrix
JT  - Matrix (Stuttgart, Germany)
JID - 8906139
RN  - 0 (Growth Substances)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Transforming Growth Factor beta)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Cell Division/drug effects
MH  - Cells, Cultured
MH  - Cicatrix/physiopathology
MH  - Collagen/*biosynthesis
MH  - DNA Replication/drug effects
MH  - Epidermal Growth Factor/pharmacology
MH  - Fibroblasts/cytology/drug effects/physiology
MH  - Growth Substances/*pharmacology
MH  - Kinetics
MH  - Male
MH  - Mouth Mucosa/cytology/drug effects/*physiology
MH  - Platelet-Derived Growth Factor/pharmacology
MH  - *Protein Biosynthesis
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Transforming Growth Factor beta/pharmacology
MH  - Wound Healing/*drug effects
EDAT- 1991/06/01 00:00
MHDA- 1991/06/01 00:01
CRDT- 1991/06/01 00:00
PHST- 1991/06/01 00:00 [pubmed]
PHST- 1991/06/01 00:01 [medline]
PHST- 1991/06/01 00:00 [entrez]
AID - 10.1016/s0934-8832(11)80158-7 [doi]
PST - ppublish
SO  - Matrix. 1991 Jun;11(3):190-6. doi: 10.1016/s0934-8832(11)80158-7.