PMID- 18705773
OWN - NLM
STAT- MEDLINE
DCOM- 20081030
LR  - 20191210
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 58
IP  - 8
DP  - 2008 Aug
TI  - Malignant pheochromocytoma in a young adult forming the structure simulating 
      Homer Wright rosette: differentiation from neuroblastoma on repeating 
      fluorescence in situ hybridization.
PG  - 518-23
LID - 10.1111/j.1440-1827.2008.02266.x [doi]
AB  - A peculiar adrenal tumor was analyzed using immunohistochemistry, electron 
      microscopy, and fluorescence in situ hybridization (FISH) with multiple bacterial 
      artificial chromosome (BAC) probes. The patient was a 34-year-old woman with a 
      mass above the left kidney and multiple metastases. Her serum and urine dopamine 
      level were elevated, and a diagnosis of malignant pheochromocytoma was made. The 
      patient died approximately 3 years after her first visit. On post-mortem an 
      adrenal tumor composed of small round cells forming Homer Wright rosette-like 
      structures, a feature rarely observed in pheochromocytoma, was found. 
      Immunohistochemistry was positive for chromogranin A and synaptophysin, and 
      negative for cytokeratin, vimentin and neurofilaments. Because these results did 
      not rule out a diagnosis of neuroblastoma, the tumor was further characterized on 
      FISH with multiple BAC probes for loci known to be altered in neuroblastoma or 
      pheochromocytoma, according to information in the literature that was for the 
      most part obtained using comparative genomic hybridization. FISH demonstrated 
      loss of heterozygosity at 11p, and gains at 16p, 19p, and 19q, a profile that 
      favored a diagnosis of malignant pheochromocytoma over neuroblastoma. This case 
      demonstrates that repeating FISH is useful for differential diagnosis.
FAU - Mori, Hiroki
AU  - Mori H
AD  - Department of Pathology, Hamamatsu University School of Medicine, Handayama, 
      Higashi-ku, Hamamatsu, Japan.
FAU - Nagata, Masao
AU  - Nagata M
FAU - Nishijima, Nariaki
AU  - Nishijima N
FAU - Nagura, Kiyoko
AU  - Nagura K
FAU - Igarashi, Hisaki
AU  - Igarashi H
FAU - Hamazaki, Minoru
AU  - Hamazaki M
FAU - Ozono, Seiichiro
AU  - Ozono S
FAU - Sugimura, Haruhiko
AU  - Sugimura H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (DNA Probes)
RN  - 0 (DNA, Neoplasm)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adrenal Gland Neoplasms/blood/genetics/*pathology
MH  - Adult
MH  - Chromosomes, Artificial, Bacterial/chemistry/genetics
MH  - DNA Probes/chemistry
MH  - DNA, Neoplasm/analysis
MH  - Diagnosis, Differential
MH  - Dopamine/blood
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Neuroblastoma/*diagnosis/genetics
MH  - Pheochromocytoma/blood/genetics/*pathology
EDAT- 2008/08/19 09:00
MHDA- 2008/10/31 09:00
CRDT- 2008/08/19 09:00
PHST- 2008/08/19 09:00 [pubmed]
PHST- 2008/10/31 09:00 [medline]
PHST- 2008/08/19 09:00 [entrez]
AID - PIN2266 [pii]
AID - 10.1111/j.1440-1827.2008.02266.x [doi]
PST - ppublish
SO  - Pathol Int. 2008 Aug;58(8):518-23. doi: 10.1111/j.1440-1827.2008.02266.x.