PMID- 18707771
OWN - NLM
STAT- MEDLINE
DCOM- 20100226
LR  - 20151119
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 137
IP  - 3
DP  - 2009 Nov 12
TI  - Osteoprotegerin and B-type natriuretic peptide in acute coronary syndromes with 
      preserved systolic function: relation to coronary artery disease extension.
PG  - 295-8
LID - 10.1016/j.ijcard.2008.05.048 [doi]
AB  - OBJECTIVES: To analyze Osteoprotegerin (OPG), and BNP plasma levels in patients 
      with non-ST elevation acute coronary syndrome (NSTE-ACS), in relation to clinical 
      presentation and to coronary atherosclerosis diffusion. METHODS: 155 CAD patients 
      were classified in four groups: stable angina (SA n=42), unstable angina (UA 
      n=35) non-ST elevation myocardial infarction (NSTEMI n=45) and control group 
      (n=33), measuring OPG and BNP at hospital admission. We compared both biomarkers 
      in relation to the number of coronary narrowed vessels (1-,2-,3 or more vessels 
      disease), and to the stenoses degree by Duke Jeopardy score. RESULTS: OPG levels 
      were higher in patients with CAD respect to controls (p<0.0001). Patients with SA 
      showed more elevated levels than controls (2.6+/-1.2 vs 7.4+/-5.0 pmol/l p<0.01). 
      However patients with UA and NSTEMI had higher OPG level with respect to SA 
      patients (12.2+/-7.8 and 11.6+/-6.1 respectively pmol/l p<0.001). A positive 
      relation was found between OPG levels and coronary plaques extension by Duke 
      Jeopardy score (r=0.65). BNP levels were higher in patients with UA/NSTEMI 
      respect to controls and SA patients (p<0.001). Besides, BNP was significantly 
      higher in patients with multi-vessels vs 1-vessel disease (p<0.001). CONCLUSIONS: 
      Patients with UA and NSTEMI show high OPG and BNP levels. OPG increase seems 
      related to the number of plaques in the coronary vessels, suggesting its 
      involvement in the CAD progression.
FAU - Palazzuoli, Alberto
AU  - Palazzuoli A
FAU - Ascione, Raimondo
AU  - Ascione R
FAU - Gallotta, Maddalena
AU  - Gallotta M
FAU - Calabro, Anna
AU  - Calabro A
FAU - Gonnelli, Stefano
AU  - Gonnelli S
FAU - Quatrini, Ilaria
AU  - Quatrini I
FAU - Campagna, Maria Stella
AU  - Campagna MS
FAU - Franci, Beatrice
AU  - Franci B
FAU - Nuti, Ranuccio
AU  - Nuti R
LA  - eng
PT  - Letter
DEP - 20080815
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Biomarkers)
RN  - 0 (Osteoprotegerin)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Acute Coronary Syndrome/*blood
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Coronary Artery Disease/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Natriuretic Peptide, Brain/*blood
MH  - Osteoprotegerin/*blood
MH  - Regression Analysis
MH  - Risk Factors
MH  - Systole
EDAT- 2008/08/19 09:00
MHDA- 2010/02/27 06:00
CRDT- 2008/08/19 09:00
PHST- 2008/02/12 00:00 [received]
PHST- 2008/05/10 00:00 [accepted]
PHST- 2008/08/19 09:00 [pubmed]
PHST- 2010/02/27 06:00 [medline]
PHST- 2008/08/19 09:00 [entrez]
AID - S0167-5273(08)00763-8 [pii]
AID - 10.1016/j.ijcard.2008.05.048 [doi]
PST - ppublish
SO  - Int J Cardiol. 2009 Nov 12;137(3):295-8. doi: 10.1016/j.ijcard.2008.05.048. Epub 
      2008 Aug 15.