PMID- 18708165
OWN - NLM
STAT- MEDLINE
DCOM- 20090630
LR  - 20141120
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 8
IP  - 1
DP  - 2008 Oct
TI  - Recurrent pericarditis: infectious or autoimmune?
PG  - 44-7
LID - 10.1016/j.autrev.2008.07.024 [doi]
AB  - The etiology and pathogenesis of idiopathic recurrent acute pericarditis (IRAP) 
      remain controversial standing like a bridge that crosses infectious, autoimmune 
      and autoinflammatory pathways. Anything may cause acute pericarditis; Echo-virus, 
      and Coxsackie are the most frequently involved viruses, Mycobacterium 
      tuberculosis and Coxiella burnetii the most common bacteria, but in 85% of cases 
      it remains "idiopathic". Recurrences occur in up to 20-50% of patients. An 
      immuno-mediated pathogenesis is suggested by the presence of pro-inflammatory 
      cytokines in pericardial fluid, the presence of antinuclear autoantibodies (ANA) 
      in sera of the patients, the occurrence of new autoimmune diagnoses and the good 
      response to anti-inflammatory or immunosuppressive therapy. Nonsteroidal 
      anti-inflammatory drugs (NSAIDs) must be used at recommended dosages, till the 
      resolution of symptoms and normalization of C-reactive protein and erythrocyte 
      sedimentation rate. Corticosteroids should be used rarely, at low doses, with an 
      extremely low tapering and with osteoporosis prevention. Colchicine leads to a 
      clinically important and statistically significant benefit, reducing recurrences 
      by 50%. The long term outcome of IRAP is good, without evidence of constriction 
      even after a very long follow-up.
FAU - Brucato, Antonio
AU  - Brucato A
AD  - Department of Internal Medicine, Ospedali Riuniti di Bergamo, Bergamo, Italy. 
      albrucato@ospedaliriuniti.bergamo.it
FAU - Maestroni, Silvia
AU  - Maestroni S
FAU - Cumetti, Davide
AU  - Cumetti D
FAU - Thiella, Giuseppe
AU  - Thiella G
FAU - Alari, Gabriella
AU  - Alari G
FAU - Brambilla, Giovanni
AU  - Brambilla G
FAU - Imazio, Massimo
AU  - Imazio M
FAU - Doria, Andrea
AU  - Doria A
FAU - Palmieri, Giancarlo
AU  - Palmieri G
FAU - Adler, Yehuda
AU  - Adler Y
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080815
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Antibodies, Antinuclear)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - SML2Y3J35T (Colchicine)
SB  - IM
MH  - Acute Disease
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Antibodies, Antinuclear/biosynthesis/*immunology
MH  - Bacterial Infections/*immunology
MH  - C-Reactive Protein/metabolism
MH  - Colchicine/therapeutic use
MH  - Coxiella burnetii
MH  - Drug Interactions
MH  - Enterovirus/*immunology
MH  - Enterovirus Infections/*immunology
MH  - Humans
MH  - Mycobacterium tuberculosis
MH  - Osteoporosis/prevention & control
MH  - Pericarditis/drug therapy/*etiology/physiopathology
MH  - Prognosis
MH  - Secondary Prevention
MH  - Treatment Outcome
RF  - 20
EDAT- 2008/08/19 09:00
MHDA- 2009/07/01 09:00
CRDT- 2008/08/19 09:00
PHST- 2008/08/19 09:00 [pubmed]
PHST- 2009/07/01 09:00 [medline]
PHST- 2008/08/19 09:00 [entrez]
AID - S1568-9972(08)00136-5 [pii]
AID - 10.1016/j.autrev.2008.07.024 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2008 Oct;8(1):44-7. doi: 10.1016/j.autrev.2008.07.024. Epub 2008 
      Aug 15.