PMID- 18709427
OWN - NLM
STAT- MEDLINE
DCOM- 20090116
LR  - 20211020
IS  - 1528-1132 (Electronic)
IS  - 0009-921X (Print)
IS  - 0009-921X (Linking)
VI  - 467
IP  - 1
DP  - 2009 Jan
TI  - Persisting high levels of synovial fluid markers after cartilage repair: a pilot 
      study.
PG  - 267-72
LID - 10.1007/s11999-008-0434-x [doi]
AB  - Local attempts to repair a cartilage lesion could cause increased levels of 
      anabolic and catabolic factors in the synovial fluid. After repair with 
      regenerated cartilage, the homeostasis of the cartilage ideally would return to 
      normal. In this pilot study, we first hypothesized levels of synovial fluid 
      markers would be higher in patients with cartilage lesions than in patients with 
      no cartilage lesions, and then we hypothesized the levels of synovial fluid 
      markers would decrease after cartilage repair. We collected synovial fluid 
      samples from 10 patients before autologous chondrocyte transplantation of the 
      knee. One year later, a second set of samples was collected and arthroscopic 
      evaluation of the repair site was performed. Fifteen patients undergoing knee 
      arthroscopy for various symptoms but with no apparent cartilage lesions served as 
      control subjects. We measured synovial fluid matrix metalloproteinase-3 (MMP-3) 
      and insulinlike growth factor-I (IGF-I) concentrations with specific activity and 
      enzyme-linked immunosorbent assays, respectively. The levels of MMP-3 and IGF-I 
      were higher in patients having cartilage lesions than in control subjects with no 
      cartilage lesions. One year after cartilage repair, the lesions were filled with 
      repair tissue, but the levels of MMP-3 and IGF-I remained elevated, indicating 
      either graft remodeling or early degeneration. LEVEL OF EVIDENCE: Level III, 
      prognostic study. See the Guidelines for Authors for a complete description of 
      levels of evidence.
FAU - Vasara, Anna I
AU  - Vasara AI
AD  - Department of Orthopaedics and Traumatology, Helsinki University Hospital, Peijas 
      Hospital, Helsinki, Finland. anna.vasara@fimnet.fi
FAU - Konttinen, Yrjo T
AU  - Konttinen YT
FAU - Peterson, Lars
AU  - Peterson L
FAU - Lindahl, Anders
AU  - Lindahl A
FAU - Kiviranta, Ilkka
AU  - Kiviranta I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080815
PL  - United States
TA  - Clin Orthop Relat Res
JT  - Clinical orthopaedics and related research
JID - 0075674
RN  - 0 (Biomarkers)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Arthroscopy
MH  - Biomarkers/*metabolism
MH  - Bone Diseases/metabolism/surgery
MH  - Chondrocytes/*transplantation
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Knee Injuries/metabolism/*surgery
MH  - Male
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Menisci, Tibial/*metabolism/*surgery
MH  - Middle Aged
MH  - Pilot Projects
MH  - Prognosis
MH  - Synovial Fluid/*metabolism
MH  - Tibial Meniscus Injuries
MH  - Transplantation, Autologous
MH  - Young Adult
PMC - PMC2601000
EDAT- 2008/08/19 09:00
MHDA- 2009/01/17 09:00
PMCR- 2010/01/01
CRDT- 2008/08/19 09:00
PHST- 2007/11/05 00:00 [received]
PHST- 2008/07/16 00:00 [accepted]
PHST- 2008/08/19 09:00 [entrez]
PHST- 2008/08/19 09:00 [pubmed]
PHST- 2009/01/17 09:00 [medline]
PHST- 2010/01/01 00:00 [pmc-release]
AID - 434 [pii]
AID - 10.1007/s11999-008-0434-x [doi]
PST - ppublish
SO  - Clin Orthop Relat Res. 2009 Jan;467(1):267-72. doi: 10.1007/s11999-008-0434-x. 
      Epub 2008 Aug 15.