PMID- 1871182
OWN - NLM
STAT- MEDLINE
DCOM- 19910919
LR  - 20190912
IS  - 0952-3278 (Print)
IS  - 0952-3278 (Linking)
VI  - 43
IP  - 3
DP  - 1991 Jul
TI  - Vascular eicosanoid production in experimental hypertensive rats with different 
      mechanisms.
PG  - 179-84
AB  - This study investigated the release of prostacyclin (PGI2) and thromboxane A2 
      (TXA2) from the aortic walls of various experimental hypertensive rats, e.g. 
      spontaneously hypertensive rats (SHR), Dahl salt-sensitive (Dahl S) rats, 
      deoxycorticosterone (DOCA)-salt hypertensive rats and renovascular (2-kidney, 
      1-clip (2K1C) and 1-kidney, 1-clip (1K1C] hypertensive rats. The PGI2 generation 
      was increased significantly in these hypertensive models, irrespective of the 
      hypertensive mechanisms, when they developed established hypertension. Dahl S 
      rats, having an impaired PGI2 production on a low salt diet, restored PGI2 
      generating capacity to the control level of Dahl salt-resistant rats when they 
      were fed a high salt diet and developed salt-induced hypertension. On the other 
      hand, the TXA2 generation in the vascular walls was enhanced particularly in rat 
      models for genetic hypertension, and this system was unaltered in the models for 
      secondary hypertension, e.g. DOCA-salt and renovascular hypertension. Thus, it is 
      suggested that the elevation of blood pressure is associated with an increase in 
      vascular PGI2 production, and that the increased vascular TXA2 production is a 
      characteristic feature of genetic hypertension.
FAU - Ishimitsu, T
AU  - Ishimitsu T
AD  - 2nd Department of Internal Medicine, University of Tokyo, Japan.
FAU - Uehara, Y
AU  - Uehara Y
FAU - Iwai, J
AU  - Iwai J
FAU - Sugimoto, T
AU  - Sugimoto T
FAU - Hirata, Y
AU  - Hirata Y
FAU - matsuoka, H
AU  - matsuoka H
FAU - Sugimoto, T
AU  - Sugimoto T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Scotland
TA  - Prostaglandins Leukot Essent Fatty Acids
JT  - Prostaglandins, leukotrienes, and essential fatty acids
JID - 8802730
RN  - 0 (Eicosanoids)
RN  - 10028-17-8 (Tritium)
RN  - 57576-52-0 (Thromboxane A2)
RN  - DCR9Z582X0 (Epoprostenol)
SB  - IM
MH  - Animals
MH  - Aorta/metabolism
MH  - Blood Pressure
MH  - Blood Vessels/*metabolism
MH  - Disease Models, Animal
MH  - Eicosanoids/*biosynthesis/metabolism
MH  - Epoprostenol/analysis/*metabolism
MH  - Hypertension/chemically induced/genetics/*metabolism
MH  - Hypertension, Renovascular/metabolism
MH  - In Vitro Techniques
MH  - Male
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred Strains
MH  - Thromboxane A2/analysis/*metabolism
MH  - Tritium
EDAT- 1991/07/01 00:00
MHDA- 1991/07/01 00:01
CRDT- 1991/07/01 00:00
PHST- 1991/07/01 00:00 [pubmed]
PHST- 1991/07/01 00:01 [medline]
PHST- 1991/07/01 00:00 [entrez]
AID - 10.1016/0952-3278(91)90166-3 [doi]
PST - ppublish
SO  - Prostaglandins Leukot Essent Fatty Acids. 1991 Jul;43(3):179-84. doi: 
      10.1016/0952-3278(91)90166-3.