PMID- 18712847
OWN - NLM
STAT- MEDLINE
DCOM- 20081030
LR  - 20220331
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 80
IP  - 10
DP  - 2008 Oct
TI  - First report on fatal myocarditis associated with adenovirus infection in Cuba.
PG  - 1756-61
LID - 10.1002/jmv.21274 [doi]
AB  - Myocarditis is caused frequently by viral infections of the myocardium. In the 
      past, enteroviruses (EV) were considered the most common cause of myocarditis in 
      all age groups. Other viruses that cause myocarditis are adenovirus and influenza 
      viruses. Parvovirus B19 infection is associated sometimes with myocarditis. 
      Members of the Herpesviridae family, cytomegalovirus (CMV), and human herpesvirus 
      6 (HHV-6) have been associated occasionally with myocarditis. During an atypical 
      outbreak of acute febrile syndrome, eight children, with ages from 5 months to 15 
      years, died in cardiogenic shock due to myocarditis in July-August 2005, in the 
      city of Havana, Cuba. Nested polymerase chain reaction (nPCR) and nested reverse 
      transcription-PCR (nRT-PCR) were carried out on fresh heart muscle and lung 
      tissue to analyze the genomic sequences of adenovirus, CMV, HHV-6, herpes simplex 
      virus, Epstein-Barr virus (EBV), varizella zoster virus, influenza virus A, B, C, 
      respiratory syncytial virus (RSV) A and B, parainfluenza viruses, rhinoviruses, 
      coronavirus, flaviruses and enteroviruses. Evidence was for the presence of the 
      adenovirus genome in 6 (75%) of the children. Phylogenetic analyses of a 
      conserved hexon gene fragment in four cases showed serotype 5 as the causal 
      agent. No others viruses were detected. Histological examination was undertaken 
      to detect myocardial inflammation. After exclusion of other possible causes of 
      death, the results indicated that viral myocarditis was the cause of death in 
      patients with adenovirus infection.
FAU - Valdes, Odalys
AU  - Valdes O
AD  - Respiratory Viruses Laboratory, Virology Department, Division of Microbiology, 
      Instituto de Medicina Tropical Pedro Kouri, Havana, Cuba. odalys@ipk.sld.cu
FAU - Acosta, Belsy
AU  - Acosta B
FAU - Pinon, Alexander
AU  - Pinon A
FAU - Savon, Clara
AU  - Savon C
FAU - Goyenechea, Angel
AU  - Goyenechea A
FAU - Gonzalez, Grehete
AU  - Gonzalez G
FAU - Gonzalez, Guelsys
AU  - Gonzalez G
FAU - Palerm, Lidice
AU  - Palerm L
FAU - Sarmiento, Luis
AU  - Sarmiento L
FAU - Pedro, Mas Lago
AU  - Pedro ML
FAU - Martinez, Pedro A
AU  - Martinez PA
FAU - Rosario, Delfina
AU  - Rosario D
FAU - Kouri, Vivian
AU  - Kouri V
FAU - Guzman, Maria Guadalupe
AU  - Guzman MG
FAU - Llop, Alina
AU  - Llop A
FAU - Casas, Inmaculada
AU  - Casas I
FAU - Perez Brena, Ma Pilar
AU  - Perez Brena MP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
SB  - IM
MH  - Adenoviridae/classification/genetics/*isolation & purification
MH  - Adenoviridae Infections/*complications/mortality/pathology/*virology
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cuba/epidemiology
MH  - *Disease Outbreaks
MH  - Female
MH  - Genome, Viral/genetics
MH  - Heart/virology
MH  - Humans
MH  - Infant
MH  - Lung/virology
MH  - Male
MH  - Myocarditis/mortality/pathology/*virology
MH  - Phylogeny
MH  - Polymerase Chain Reaction
MH  - Sequence Analysis, DNA
MH  - Shock, Cardiogenic/mortality/pathology/*virology
PMC - PMC7159136
EDAT- 2008/08/21 09:00
MHDA- 2008/10/31 09:00
PMCR- 2020/04/15
CRDT- 2008/08/21 09:00
PHST- 2008/08/21 09:00 [pubmed]
PHST- 2008/10/31 09:00 [medline]
PHST- 2008/08/21 09:00 [entrez]
PHST- 2020/04/15 00:00 [pmc-release]
AID - JMV21274 [pii]
AID - 10.1002/jmv.21274 [doi]
PST - ppublish
SO  - J Med Virol. 2008 Oct;80(10):1756-61. doi: 10.1002/jmv.21274.