PMID- 18713231
OWN - NLM
STAT- MEDLINE
DCOM- 20090414
LR  - 20210409
IS  - 1468-3083 (Electronic)
IS  - 0926-9959 (Linking)
VI  - 23
IP  - 1
DP  - 2009 Jan
TI  - The role of human herpesvirus 6, human herpesvirus 7, Epstein-Barr virus and 
      cytomegalovirus in the aetiology of pityriasis rosea.
PG  - 16-21
LID - 10.1111/j.1468-3083.2008.02939.x [doi]
AB  - AIM: To identify the role of human herpesvirus 6 (HHV-6), HHV-7, Epstein-Barr 
      virus (EBV) and cytomegalovirus (CMV) in the pathogenesis of pityriasis rosea 
      (PR). MATERIAL: Polymerase chain reaction with specific primers for HHV-6 and 
      HHV-7 DNA sequences was performed on the blood and tissue samples of 25 patients 
      with PR and on the blood samples of age- and sex-matched healthy controls. HHV-6, 
      EBV, CMV immunoglobulin M (IgM) and IgG were analysed by enzyme-linked 
      immunosorbent assay, HHV-7 IgM and IgG were analysed by indirect 
      immunofluorescence on the serum samples of the study population. In the patient 
      group, the values were studied 2 weeks later again (second control). RESULTS: 
      There were no differences between the first and second controls of the patients 
      and healthy subjects regarding HHV-6 IgM, HHV-7 IgM, CMV IgM, EBV IgM results. 
      There were significant differences between the first [HHV-6 DNA (2 of 25), HHV-7 
      DNA (6 of 25)] and second control [HHV-6 DNA (1 of 25), HHV-7 DNA (11 of 25)] of 
      the patients for the blood samples in favour of HHV-7. PR patients showed higher 
      amounts of HHV-6 and HHV-7 DNA positivity when compared with that of healthy 
      subjects. HHV-7 seemed to be more important regarding tissue samples [HHV-6 DNA 
      (7 of 25), HHV-7 DNA (12 of 25) first control, HHV-6 DNA (6 of 25), HHV-7 DNA (12 
      of 25) second control] as well as blood samples. CONCLUSION: Though our results 
      failed to support a causal relationship among EBV, CMV and PR, they indicated a 
      possible role for HHV-6 and especially HHV-7 in a group of Turkish patients but 
      other aetiological factors may exist.
FAU - Canpolat Kirac, B
AU  - Canpolat Kirac B
AD  - Department of Dermatology, Gazi University, Besevler, Ankara, Turkey. 
      bilgederm@gmail.com
FAU - Adisen, E
AU  - Adisen E
FAU - Bozdayi, G
AU  - Bozdayi G
FAU - Yucel, A
AU  - Yucel A
FAU - Fidan, I
AU  - Fidan I
FAU - Aksakal, N
AU  - Aksakal N
FAU - Gurer, M A
AU  - Gurer MA
LA  - eng
PT  - Journal Article
DEP - 20080818
PL  - England
TA  - J Eur Acad Dermatol Venereol
JT  - Journal of the European Academy of Dermatology and Venereology : JEADV
JID - 9216037
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Antibodies, Viral/blood
MH  - Cytomegalovirus/genetics/immunology/*physiology
MH  - DNA, Viral/blood
MH  - Female
MH  - Fluorescent Antibody Technique, Indirect
MH  - Herpesvirus 4, Human/genetics/immunology/*physiology
MH  - Herpesvirus 6, Human/genetics/immunology/*physiology
MH  - Herpesvirus 7, Human/genetics/immunology/*physiology
MH  - Humans
MH  - Male
MH  - Pityriasis Rosea/*etiology/virology
MH  - Polymerase Chain Reaction
EDAT- 2008/08/21 09:00
MHDA- 2009/04/15 09:00
CRDT- 2008/08/21 09:00
PHST- 2008/08/21 09:00 [pubmed]
PHST- 2009/04/15 09:00 [medline]
PHST- 2008/08/21 09:00 [entrez]
AID - JDV2939 [pii]
AID - 10.1111/j.1468-3083.2008.02939.x [doi]
PST - ppublish
SO  - J Eur Acad Dermatol Venereol. 2009 Jan;23(1):16-21. doi: 
      10.1111/j.1468-3083.2008.02939.x. Epub 2008 Aug 18.