PMID- 18716631
OWN - NLM
STAT- MEDLINE
DCOM- 20081023
LR  - 20211020
IS  - 1460-2075 (Electronic)
IS  - 0261-4189 (Print)
IS  - 0261-4189 (Linking)
VI  - 27
IP  - 18
DP  - 2008 Sep 17
TI  - Nuclear receptor signalling in dendritic cells connects lipids, the genome and 
      immune function.
PG  - 2353-62
LID - 10.1038/emboj.2008.160 [doi]
AB  - Dendritic cells (DCs) are sentinels of the immune system and represent a 
      heterogeneous cell population. The existence of distinct DC subsets is due to 
      their inherent plasticity and to the changing microenvironment modulating their 
      immunological properties. Numerous signalling pathways have impacts on DCs. It 
      appears that besides cytokines/chemokines, lipid mediators also have profound 
      effects on the immunogenicity of DCs. Some of these lipid mediators exert an 
      effect through nuclear hormone receptors. Interestingly, more recent findings 
      suggest that DCs are able to convert precursors to active hormones, ligands for 
      nuclear receptors. Some of these DC-derived lipids, in particular retinoic acid 
      (RA), have a central function in shaping T-cell development and effector 
      functions. In this review, we summarize and highlight the function of a set of 
      nuclear receptors (PPARgamma, RA receptor, vitamin D receptor and glucocorticoid 
      receptor) in DC biology. Defining the contribution of nuclear hormone receptor 
      signalling in DCs can help one to understand the regulatory logic of lipid 
      signalling and allow the exploitation of their potential for therapeutic 
      intervention in various immunological diseases.
FAU - Szatmari, Istvan
AU  - Szatmari I
AD  - Department of Biochemistry and Molecular Biology, Medical and Health Science 
      Center, University of Debrecen, Debrecen, Hungary.
FAU - Nagy, Laszlo
AU  - Nagy L
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 074021/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080821
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Lipids)
RN  - 0 (PPAR gamma)
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 0 (Receptors, Retinoic Acid)
SB  - IM
MH  - Animals
MH  - Cell Nucleus/metabolism
MH  - Dendritic Cells/*cytology
MH  - Genome
MH  - Humans
MH  - Immune System
MH  - Lipids/*chemistry
MH  - Models, Biological
MH  - PPAR gamma/metabolism
MH  - Receptors, Calcitriol/metabolism
MH  - Receptors, Cytoplasmic and Nuclear/*metabolism
MH  - Receptors, Glucocorticoid/metabolism
MH  - Receptors, Retinoic Acid/metabolism
MH  - *Signal Transduction
PMC - PMC2525841
EDAT- 2008/08/22 09:00
MHDA- 2008/10/24 09:00
PMCR- 2008/09/17
CRDT- 2008/08/22 09:00
PHST- 2008/04/23 00:00 [received]
PHST- 2008/07/24 00:00 [accepted]
PHST- 2008/08/22 09:00 [pubmed]
PHST- 2008/10/24 09:00 [medline]
PHST- 2008/08/22 09:00 [entrez]
PHST- 2008/09/17 00:00 [pmc-release]
AID - emboj2008160 [pii]
AID - 10.1038/emboj.2008.160 [doi]
PST - ppublish
SO  - EMBO J. 2008 Sep 17;27(18):2353-62. doi: 10.1038/emboj.2008.160. Epub 2008 Aug 
      21.