PMID- 18716994
OWN - NLM
STAT- MEDLINE
DCOM- 20081113
LR  - 20211203
IS  - 1332-8166 (Electronic)
IS  - 0353-9504 (Print)
IS  - 0353-9504 (Linking)
VI  - 49
IP  - 4
DP  - 2008 Aug
TI  - Genetic polymorphisms at HLA-A, -B, and -DRB1 loci in Han population of Xi'an 
      city in China.
PG  - 476-82
AB  - AIM: To determine genetic polymorphisms at human leukocyte antigen (HLA)-A, -B, 
      and -DRB1 loci in Han population of Xi'an city in China. METHODS: Polymerase 
      chain reaction-based reverse line-strip sequence specific oligonucleotide 
      hybridization was used to determine the alleles of HLA-A, -B, and -DRB1 in 516 
      unrelated, healthy individuals of Han population in Xi'an. Allele frequencies at 
      HLA-A, -B, and -DRB1 loci were estimated by direct counting method. Haplotype 
      frequencies were calculated from genotype data by expectation maximization. 
      RESULTS: A total of 14 alleles of HLA-A, 33 alleles of HLA-B, and 13 alleles of 
      HLA-DRB1 were found. The most common alleles were HLA-A*02 (28.39%), A*11 
      (19.19%), and A*24 (16.28%); HLA-B*13 (11.05%), B*15 (B62: 9.30%), and B*51 
      (8.53%); and HLA-DRB1*15 (17.15%), DRB1*09 (13.18%), and DRB1*04 (10.85%). The 
      most common haplotypes of HLA-A-B-DRB1 haplotype were HLA-A*30-B*13-DRB1*07 
      (3.93%), HLA-A*02-B*46-DRB1*09 (3.20%), and HLA-A*33-B*58-DRB1*17 (1.63%). 
      CONCLUSION: The finding that the HLA loci are highly polymorphic in Han 
      population of Xi'an City may be useful for population genetics, HLA-related 
      studies, human identification, and paternity tests in forensic sciences.
FAU - Shen, Chunmei
AU  - Shen C
AD  - Department of Forensic Medicine, School of Medicine, Xi'an Jiaotong University, 
      Xi'an, 710061 Shaanxi, P. R. China.
FAU - Zhu, Bofeng
AU  - Zhu B
FAU - Liu, Mengli
AU  - Liu M
FAU - Li, Shengbin
AU  - Li S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Croatia
TA  - Croat Med J
JT  - Croatian medical journal
JID - 9424324
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - China
MH  - Ethnicity
MH  - Genetics, Population
MH  - Genotype
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Pilot Projects
MH  - Polymorphism, Genetic/*genetics
PMC - PMC2525824
EDAT- 2008/08/22 09:00
MHDA- 2008/11/14 09:00
CRDT- 2008/08/22 09:00
PHST- 2008/08/22 09:00 [pubmed]
PHST- 2008/11/14 09:00 [medline]
PHST- 2008/08/22 09:00 [entrez]
AID - CroatMedJ_49_0476 [pii]
AID - 10.3325/cmj.2008.4.476 [doi]
PST - ppublish
SO  - Croat Med J. 2008 Aug;49(4):476-82. doi: 10.3325/cmj.2008.4.476.