PMID- 18717311
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20080822
IS  - 1673-0860 (Print)
IS  - 1673-0860 (Linking)
VI  - 43
IP  - 5
DP  - 2008 May
TI  - [Primary study on glycan structure in pathopoiesis mechanism of recurrent 
      respiratory papillomatosis].
PG  - 355-9
AB  - OBJECTIVE: To compare the molecular basis difference between recurrent 
      respiratory papillomatosis (RRP) and vocal cord polyp, to analyze the expression 
      of glycan structural genes, and to discuss the pathopoiesis mechanism of RRP. 
      METHODS: The gene expressing profile between the 3 groups papilloma and the vocal 
      cord polyp regarded as normal larynx epithelium were compared using mRNA parallel 
      amplify and the human genome gene expressing microarray. Through cluster 
      analysis, Gene Ontology function gene annotation and path way analysis, the 
      relative gene of RRP and HPV infection were acquired. RESULTS: According to three 
      microarrays results, total 567 expression changed genes related to HPV induce RRP 
      were acquired. A serial change of glycan structure biosynthesis and degradation 
      pathways was significant. The expression of dolichyl-phosphate 
      mannosyltransferase polypeptide 1 (DPM1), asparagine-linked glycosylation 1 
      homolog (ALG1), fucosyltransferase 8 (FUT8) and alpha-mannosidase 1A (MAN1A) were 
      regulated and beta-hexosaminidase (HEXB), beta1-galactosidase (GLB1), exostoses 1 
      (EXT1), fucosyltransferase (FUT) reduced expression and heparan sulfate 
      3-O-sulfotransferase 1 (HS3ST3A1) increased expression. The two related enzymes 
      of the glycosphingolipids which is the main composed of the cell membrane, 
      beta-3-N-acetylglucosaminyltransferase 4 (B3GNT4) and UDP-glucose ceramide 
      glucosyltransferase (UGCG) increase expression, HEXB and GLB1 reduced expression. 
      CONCLUSIONS: The alteration of the coding genes of glycan structure biosynthesis 
      and degradation pathways were significantly and characteristically in 
      pathopoiesis mechanism of RRP. This abnormality may be the beginning of tumor 
      form HPV infection.
FAU - Wang, Jun
AU  - Wang J
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren 
      Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and 
      Neck Surgery, Ministry of Education, Beijing 100730, China.
FAU - Han, De-Min
AU  - Han DM
FAU - Kang, Hong-Wei
AU  - Kang HW
FAU - Ma, Li-Jing
AU  - Ma LJ
FAU - Ye, Jing-Ying
AU  - Ye JY
FAU - Xiao, Yang
AU  - Xiao Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of 
      otorhinolaryngology head and neck surgery
JID - 101247574
RN  - 0 (Glycolipids)
RN  - 0 (Glycoproteins)
RN  - 0 (Oligoribonucleotides)
SB  - IM
MH  - Adult
MH  - Gene Expression Profiling
MH  - Glycolipids/genetics
MH  - Glycoproteins/genetics
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/*pathology/virology
MH  - Oligoribonucleotides/genetics
MH  - Papilloma/*genetics/*pathology/virology
MH  - Papillomaviridae/genetics
MH  - Polyps/genetics/pathology/virology
MH  - Respiratory Tract Neoplasms/*genetics/*pathology/virology
MH  - Vocal Cords/pathology
EDAT- 2008/08/23 09:00
MHDA- 2011/03/22 06:00
CRDT- 2008/08/23 09:00
PHST- 2008/08/23 09:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
PHST- 2008/08/23 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 May;43(5):355-9.