PMID- 18718631
OWN - NLM
STAT- MEDLINE
DCOM- 20081222
LR  - 20131121
IS  - 0045-6535 (Print)
IS  - 0045-6535 (Linking)
VI  - 73
IP  - 6
DP  - 2008 Oct
TI  - Congener-specific analysis of non-dioxin-like polychlorinated biphenyls in blood 
      collected from 195 pregnant women in Sapporo City, Japan.
PG  - 923-31
LID - 10.1016/j.chemosphere.2008.06.071 [doi]
AB  - We conducted a congener-specific analysis of non-dioxin-like polychlorinated 
      biphenyls (non-dioxin-like PCBs) in blood collected between July 2002 and July 
      2004 from 195 pregnant women living in Sapporo City of Hokkaido Prefecture, 
      Japan. The present study is one of the few studies in which full congener 
      concentrations of non-dioxin-like PCBs have been measured in the blood of 
      pregnant women. Of the 195 pregnant women, 101 were primipara (mean: 28.8 years, 
      median: 28.0 years) and 94 were multipara (mean: 32.3 years, median: 33.0 years). 
      Among the 197 non-dioxin-like PCB congeners, 58 congeners were identified in the 
      blood of pregnant women. The arithmetic mean total concentrations of 58 
      non-dioxin-like PCB congeners in the blood of primiparous and multiparous mothers 
      in Sapporo City were 42.2-329.3 (mean: 114.5, median: 98.6) and 31.5-258.0 (mean: 
      100.3, median: 91.4)ngg(-1)lipid, respectively. The results show that the 
      contamination of non-dioxin-like PCBs in the blood of women has decreased 
      compared to past levels in other domestic areas, in which the subject age was 
      similar to that in this study. The results of the present study indicate that 
      current levels of non-dioxin-like PCBs in the blood of Japanese women and can be 
      used as baseline data for future temporal trends. The sums of the ratios of the 
      concentrations of hexaCBs and heptaCBs to the total concentrations of 58 
      non-dioxin-like PCB congeners in the blood of primiparous and multiparous mothers 
      were 78.5% and 77.7%, respectively. The hexaCBs ratios in the blood of 
      primiparous and multiparous mothers were 45.4% and 44.7%, respectively. 
      HexaCB-153 among hexaCBs congeners, the most abundant congener in the blood of 
      primiparous and multiparous mothers, contributed approximately 22.0% and 21.8% to 
      the total concentrations of 58 non-dioxin-like PCBs congeners that were measured 
      in the blood, respectively. Among the non-dioxin-like PCB congeners measured in 
      the present study, hexaCB-138, heptaCB-170, heptaCB-180, and 
      heptaCB-182/heptaCB-187 also showed high ratios to total concentrations of 58 
      non-dioxin-like PCB congeners detected in the blood of primiparous and 
      multiparous mothers. With regard to the relationship between the total 
      concentrations of 58 non-dioxin-like PCB congeners in maternal blood and the 
      number of deliveries or the age of primiparous and multifarious mothers, the 
      total levels of these PCB congeners tended to decreases with increases in the 
      number of deliveries and significantly increased with increasing maternal age in 
      both groups. Furthermore, significant correlations were observed between the 
      total concentrations of these PCB congeners in blood and the age of primiparae 
      and multiparae. The concentrations of hexaCB-153 in the blood of primiparous and 
      multiparous mothers showed a close correlation to the total concentrations of 
      these PCBs, suggesting that hexaCB-153 could be an indicator of total 
      concentrations of non-dioxin-like PCB congeners in the blood of pregnant women.
FAU - Todaka, Takashi
AU  - Todaka T
AD  - Department of Dermatology, Graduate School of Medical Sciences, Kyushu 
      University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. 
      todaka@fihes.pref.fukuoka.jp
FAU - Hori, Tsuguhide
AU  - Hori T
FAU - Hirakawa, Hironori
AU  - Hirakawa H
FAU - Kajiwara, Jumboku
AU  - Kajiwara J
FAU - Yasutake, Daisuke
AU  - Yasutake D
FAU - Onozuka, Daisuke
AU  - Onozuka D
FAU - Kato, Shizue
AU  - Kato S
FAU - Sasaki, Seiko
AU  - Sasaki S
FAU - Nakajima, Sonomi
AU  - Nakajima S
FAU - Saijo, Yasuaki
AU  - Saijo Y
FAU - Sata, Fumihiro
AU  - Sata F
FAU - Kishi, Reiko
AU  - Kishi R
FAU - Iida, Takao
AU  - Iida T
FAU - Furue, Masutaka
AU  - Furue M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080820
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood/*chemistry
MH  - Female
MH  - Humans
MH  - Japan
MH  - Middle Aged
MH  - Parity
MH  - Polychlorinated Biphenyls/*blood/*chemistry
MH  - Pregnancy
EDAT- 2008/08/23 09:00
MHDA- 2008/12/23 09:00
CRDT- 2008/08/23 09:00
PHST- 2008/04/10 00:00 [received]
PHST- 2008/06/26 00:00 [revised]
PHST- 2008/06/29 00:00 [accepted]
PHST- 2008/08/23 09:00 [pubmed]
PHST- 2008/12/23 09:00 [medline]
PHST- 2008/08/23 09:00 [entrez]
AID - S0045-6535(08)00865-5 [pii]
AID - 10.1016/j.chemosphere.2008.06.071 [doi]
PST - ppublish
SO  - Chemosphere. 2008 Oct;73(6):923-31. doi: 10.1016/j.chemosphere.2008.06.071. Epub 
      2008 Aug 20.