PMID- 18720168
OWN - NLM
STAT- MEDLINE
DCOM- 20100105
LR  - 20191111
IS  - 1532-2513 (Electronic)
IS  - 0892-3973 (Linking)
VI  - 30
IP  - 4
DP  - 2008
TI  - Effect of restraint stress duration on humoral immune response in albino rats: 
      modulation by chlordiazepoxide.
PG  - 701-9
LID - 10.1080/08923970802278235 [doi]
AB  - We evaluated the effect of restraint stress (1 hr/day) for 6, 10, 14 and 21 days 
      on antibody response against sheep RBC (SRBC) and modulation by chlordiazepoxide 
      (CDP) pretreatment (10 mg/kg/day) in albino rats. Anti-SRBC titer was 
      significantly decreased with increase in number of days of restraint stress 
      exposure. CDP pretreatment significantly reversed the effects of 6, 10 and 14 
      (but not of 21) days of restraint stress. CDP treatment for 21 days per se 
      suppressed immune response, but no additive effect was observed. CDP was not 
      effective in chronic stress (i.e., 21 days of stress). Hence, the rationale 
      behind benzodiazepines therapy in chronic stress needs to be evaluated.
FAU - Suresh, Padmanaban S
AU  - Suresh PS
AD  - Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical 
      Education and Research, Pondicherry, India.
FAU - Doureradjou, Peroumal
AU  - Doureradjou P
FAU - Nandakumar, Dalavikodihalli Nanjaiah
AU  - Nandakumar DN
FAU - Koner, Bidhan Chandra
AU  - Koner BC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Anti-Anxiety Agents)
RN  - 6RZ6XEZ3CR (Chlordiazepoxide)
SB  - IM
MH  - Animals
MH  - Anti-Anxiety Agents/pharmacology/*therapeutic use
MH  - Chlordiazepoxide/pharmacology/*therapeutic use
MH  - Female
MH  - Immunity, Humoral/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Restraint, Physical
MH  - Stress, Physiological/*drug effects/*immunology
EDAT- 2008/08/23 09:00
MHDA- 2010/01/06 06:00
CRDT- 2008/08/23 09:00
PHST- 2008/08/23 09:00 [pubmed]
PHST- 2010/01/06 06:00 [medline]
PHST- 2008/08/23 09:00 [entrez]
AID - 901445164 [pii]
AID - 10.1080/08923970802278235 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2008;30(4):701-9. doi: 10.1080/08923970802278235.