PMID- 18721269
OWN - NLM
STAT- MEDLINE
DCOM- 20081020
LR  - 20080825
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 72
IP  - 2
DP  - 2008 Aug
TI  - Existence of an immunoglobulin G component of naturally occurring HLA class I 
      antibodies that are not directed against self-antigens in human serum.
PG  - 98-104
LID - 10.1111/j.1399-0039.2008.01074.x [doi]
AB  - We compared the frequency of immunoglobulin G (IgG) type of human leukocyte 
      antigen (HLA) class I antibodies between patients with systemic lupus 
      erythematosus (SLE) and healthy controls using a highly sensitive FlowPRA method. 
      Sixteen of 130 normal healthy males and 2 of 10 normal females without a history 
      of pregnancy (none had ever been transfused) possessed HLA class I antibodies. In 
      SLE, male, but not female patients, showed a significant increase in the 
      frequency of the antibodies compared with the corresponding controls. The 
      antibodies did not appear to be involved in the development of SLE because of no 
      substantial relationship to the incidence of cytopenia or SLE disease activity 
      index score. Each individual had 1-31 types of HLA class I antibodies. 
      Interestingly, HLA class I antibodies did not correspond to the individual's own 
      HLA antigens. Eight of 32 types of HLA class I antigens detected were rare in the 
      Japanese population. These results suggest that an IgG component of naturally 
      occurring HLA class I antibodies exists in human serum and that these antibodies 
      are not antibodies against self-antigens.
FAU - Zhou, B
AU  - Zhou B
AD  - Department of Pediatrics, Shinshu University School of Medicine, Asahi, 
      Matsumoto, Japan.
FAU - Saito, S
AU  - Saito S
FAU - Nakazawa, Y
AU  - Nakazawa Y
FAU - Kobayashi, N
AU  - Kobayashi N
FAU - Matsuda, M
AU  - Matsuda M
FAU - Matsumoto, Y
AU  - Matsumoto Y
FAU - Hosoyama, T
AU  - Hosoyama T
FAU - Koike, K
AU  - Koike K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Antibodies)
RN  - 0 (Autoantigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies/*blood/immunology
MH  - Autoantigens/*blood/immunology
MH  - Case-Control Studies
MH  - Child
MH  - Family
MH  - Female
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Immunoglobulin G/*immunology
MH  - Lupus Erythematosus, Systemic/*blood/immunology
MH  - Male
MH  - Middle Aged
EDAT- 2008/08/30 09:00
MHDA- 2008/10/22 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2008/10/22 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - TAN1074 [pii]
AID - 10.1111/j.1399-0039.2008.01074.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Aug;72(2):98-104. doi: 10.1111/j.1399-0039.2008.01074.x.