PMID- 18721271
OWN - NLM
STAT- MEDLINE
DCOM- 20081020
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 72
IP  - 2
DP  - 2008 Aug
TI  - HLA-A, -B and -DRB1 allele frequencies in the Bangladeshi population.
PG  - 115-9
LID - 10.1111/j.1399-0039.2008.01079.x [doi]
AB  - Population genetic studies have become an invaluable tool because of the extreme 
      polymorphism found at some of the loci of the human leukocyte antigen (HLA) 
      system. In this study, we are reporting for the first time the genetic 
      polymorphism of 141 healthy unrelated Bangladeshi Bangalees living in central 
      region of Dhaka. We studied the HLA-A, -B and -DRB1 loci using polymerase chain 
      reaction with sequence-specific primers. The allelic frequencies, two and three 
      locus haplotype frequencies were statistically analyzed. A total of 16 HLA-A 
      alleles, 26 HLA-B alleles and 14 HLA-DRB1 alleles were detected. A*33-B*44 
      (8.15%) was the most common two loci class 1 haplotype, whereas A*33-B*44-DRB1*07 
      (6.38%) was the most frequent three loci haplotype. The most common HLA-A, HLA-B 
      and HLA-DRB1 alleles were A*33 (17.02%), B*15 (19.5%) and DRB1*15 (29.07%), 
      respectively. Construction of phylogenetic tree using average linkage between 
      groups and correspondence analysis showed close associations with Indian 
      non-tribal random Dravidians, north Indian Hindus and some relations with 
      Mongolian and Pakistani populations. We believe this data will provide useful 
      information for bone marrow registry, legal medicine, disease association and 
      anthropological studies.
FAU - Ali, Md Eunus
AU  - Ali ME
AD  - Department of Forensic Medicine, National Forensic DNA Profiling Laboratory, 
      Dhaka Medical College, Dhaka, Bangladesh.
FAU - Ahmed, M U
AU  - Ahmed MU
FAU - Alam, S
AU  - Alam S
FAU - Rahman, Md Hafizur
AU  - Rahman MH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Bangladesh
MH  - Cluster Analysis
MH  - Gene Frequency
MH  - Genetics, Population
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - *Polymorphism, Genetic
EDAT- 2008/08/30 09:00
MHDA- 2008/10/22 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2008/10/22 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - TAN1079 [pii]
AID - 10.1111/j.1399-0039.2008.01079.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Aug;72(2):115-9. doi: 10.1111/j.1399-0039.2008.01079.x.