PMID- 18721272
OWN - NLM
STAT- MEDLINE
DCOM- 20081020
LR  - 20220331
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 72
IP  - 2
DP  - 2008 Aug
TI  - Genetic affinities of north and northeastern populations of India: inference from 
      HLA-based study.
PG  - 120-30
LID - 10.1111/j.1399-0039.2008.01083.x [doi]
AB  - India is like a microcosm of the world in terms of its diversity; religion, 
      climate and ethnicity which leads to genetic variations in the populations. As a 
      highly polymorphic marker, the human leukocyte antigen (HLA) system plays an 
      important role in the genetic differentiation studies. To assess the genetic 
      diversity of HLA class II loci, we studied a total of 1336 individuals from north 
      India using DNA-based techniques. The study included four endogamous castes 
      (Kayastha, Mathurs, Rastogies and Vaishyas), two inbreeding Muslim populations 
      (Shias and Sunnis) from north India and three northeast Indian populations 
      (Lachung, Mech and Rajbanshi). A total of 36 alleles were observed at DRB1 locus 
      in both Hindu castes and Muslims from north, while 21 alleles were seen in 
      northeast Indians. At the DQA1 locus, the number of alleles ranged from 11 to 17 
      in the studied populations. The total number of alleles at DQB1 was 19, 12 and 20 
      in the studied castes, Muslims and northeastern populations, respectively. The 
      most frequent haplotypes observed in all the studied populations were 
      DRB1*0701-DQA1*0201-DQB1*0201 and DRB1*1501-DQA1*0103-DQB1*0601. Upon comparing 
      our results with other world populations, we observed the presence of Caucasoid 
      element in north Indian population. However, differential admixturing among 
      Sunnis and Shias with the other north Indians was evident. Northeastern 
      populations showed genetic affinity with Mongoloids from southeast Asia. When 
      genetic distances were calculated, we found the north Indians and northeastern 
      populations to be markedly unrelated.
FAU - Agrawal, S
AU  - Agrawal S
AD  - Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical 
      Sciences, Lucknow, Uttar Pradesh, India. suraksha@sgpgi.ac.in
FAU - Srivastava, S K
AU  - Srivastava SK
FAU - Borkar, M
AU  - Borkar M
FAU - Chaudhuri, T K
AU  - Chaudhuri TK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Gene Frequency
MH  - Genetic Drift
MH  - *Genetic Speciation
MH  - *Genetic Variation
MH  - Genetics, Population
MH  - Geography
MH  - HLA Antigens/*genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - India
MH  - Phylogeny
MH  - Population Groups/*genetics
EDAT- 2008/08/30 09:00
MHDA- 2008/10/22 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2008/10/22 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - TAN1083 [pii]
AID - 10.1111/j.1399-0039.2008.01083.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Aug;72(2):120-30. doi: 10.1111/j.1399-0039.2008.01083.x.