PMID- 18721323
OWN - NLM
STAT- MEDLINE
DCOM- 20080924
LR  - 20211020
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 153 Suppl 1
IP  - Suppl 1
DP  - 2008 Sep
TI  - Allergy and the lung.
PG  - 12-6
LID - 10.1111/j.1365-2249.2008.03715.x [doi]
AB  - Among the 'allergic' conditions involving the lung, asthma is the more frequent 
      and the most extensively investigated, although asthma itself may be caused by 
      different disorders. The triggering event in allergic subjects is the reaction 
      allergen-specific immunoglobulin E (IgE) that activates mast cells and initiates 
      a complex and redundant inflammatory process, where cells, cytokines and adhesion 
      molecules are involved at different stages. In fact, mucosal eosinophilic 
      inflammation is one of the distinctive features of asthma and the particular T 
      helper type 2 (Th2) phenotype of allergic patients favours it. In general, the 
      clinical severity of asthma correlates well with the degree of inflammation. None 
      the less, other phenomena such as non-specific bronchial hyperresponsiveness and 
      remodelling intervene in the pathophysiology of allergic asthma. These phenomena 
      are only partially inflammation-related. In particular, the remodelling of the 
      bronchial wall seems to start very early in life and also seems to be a 
      distinctive histological feature of the asthmatic bronchus. The recent 
      introduction of biological treatments (monoclonal antibodies) has allowed 
      elucidation of some of the pathogenic features of allergic asthma.
FAU - Passalacqua, G
AU  - Passalacqua G
AD  - Allergy and Respiratory Diseases, Department of Internatl Medicine, San Martino 
      Hospital, Padigliano Maragliano, Italy. passalacqua@unige.it
FAU - Ciprandi, G
AU  - Ciprandi G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Asthma/*immunology/physiopathology
MH  - Bronchi/immunology
MH  - Bronchoconstriction/immunology
MH  - Cytokines/immunology
MH  - Eosinophils/immunology
MH  - Humans
MH  - Hypersensitivity/*immunology/physiopathology
MH  - Immunoglobulin E/immunology
MH  - Lung/*immunology/physiopathology
MH  - Mast Cells/immunology
MH  - Th2 Cells/immunology
PMC - PMC2515353
EDAT- 2008/09/06 09:00
MHDA- 2008/09/25 09:00
PMCR- 2009/09/01
CRDT- 2008/09/06 09:00
PHST- 2008/09/06 09:00 [pubmed]
PHST- 2008/09/25 09:00 [medline]
PHST- 2008/09/06 09:00 [entrez]
PHST- 2009/09/01 00:00 [pmc-release]
AID - CEI3715 [pii]
AID - 10.1111/j.1365-2249.2008.03715.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2008 Sep;153 Suppl 1(Suppl 1):12-6. doi: 
      10.1111/j.1365-2249.2008.03715.x.