PMID- 18721325 OWN - NLM STAT- MEDLINE DCOM- 20080924 LR - 20240511 IS - 1365-2249 (Electronic) IS - 0009-9104 (Print) IS - 0009-9104 (Linking) VI - 153 Suppl 1 IP - Suppl 1 DP - 2008 Sep TI - Allergy and the nose. PG - 22-6 LID - 10.1111/j.1365-2249.2008.03717.x [doi] AB - Allergic rhinitis (AR) is the most common immunological disorder and is characterized by an immunoglobulin E (IgE)-mediated inflammation induced by the allergen exposure. This review will consider some issues concerning pathophysiological aspects of AR: impact on asthma, response to decongestion, link with infections, response to specific immunotherapy, relationship with adiposity, effects on quality of life (QoL) and allergic inflammation. AR, even though not a serious illness, may be a clinically relevant disorder as it may present numerous complications and affect QoL, as reported in this review. Therefore, the management of AR patients should be rigorously careful and multi-disciplinary. FAU - Ciprandi, G AU - Ciprandi G AD - Semeiotica e Metodologia Medica I, Department of Internal Medicine, University of Genoa, Genoa, Italy. gio.cip@libero.it FAU - Passalacqua, G AU - Passalacqua G LA - eng PT - Journal Article PT - Review PL - England TA - Clin Exp Immunol JT - Clinical and experimental immunology JID - 0057202 RN - 0 (Allergens) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Allergens/*immunology MH - Animals MH - Eosinophilia/immunology MH - Humans MH - Hypersensitivity/*immunology MH - Immunoglobulin E/immunology MH - Nasal Mucosa/*immunology MH - Rhinitis/*immunology MH - Th2 Cells/immunology PMC - PMC2515355 EDAT- 2008/09/06 09:00 MHDA- 2008/09/25 09:00 PMCR- 2009/09/01 CRDT- 2008/09/06 09:00 PHST- 2008/09/06 09:00 [pubmed] PHST- 2008/09/25 09:00 [medline] PHST- 2008/09/06 09:00 [entrez] PHST- 2009/09/01 00:00 [pmc-release] AID - CEI3717 [pii] AID - 10.1111/j.1365-2249.2008.03717.x [doi] PST - ppublish SO - Clin Exp Immunol. 2008 Sep;153 Suppl 1(Suppl 1):22-6. doi: 10.1111/j.1365-2249.2008.03717.x.