PMID- 18722223
OWN - NLM
STAT- MEDLINE
DCOM- 20081009
LR  - 20131121
IS  - 0194-5998 (Print)
IS  - 0194-5998 (Linking)
VI  - 139
IP  - 3
DP  - 2008 Sep
TI  - Double-blind, placebo-controlled trial with esomeprazole for symptoms and signs 
      associated with laryngopharyngeal reflux.
PG  - 414-20
LID - 10.1016/j.otohns.2008.06.003 [doi]
AB  - OBJECTIVE: To determine the efficacy of proton pump inhibitor (PPI) therapy with 
      esomeprazole on symptoms and signs associated with laryngopharyngeal reflux 
      (LPR). STUDY DESIGN AND METHODS: Prospective, double-blind, randomized, 
      placebo-controlled study. Sixty-two patients with a reflux finding score (RFS)>7 
      and a reflux symptom index (RSI)>13 were enrolled and received either 
      esomeprazole 20 mg twice daily or placebo for three months. RSI and RFS were 
      assessed at baseline, after six weeks, and after three months. RESULTS: 
      Reductions of total RSI and RFS as well as of several subscores were 
      significantly higher in the treatment group compared to placebo after three 
      months (P<0.05 each). The difference between study groups was most pronounced for 
      posterior commissure hypertrophy (P<0.01). CONCLUSION: In the treatment of 
      LPR-related symptoms a high placebo effect can be observed. However, compared to 
      control, twice-daily PPI treatment for three months demonstrated a significantly 
      greater improvement in laryngeal appearance and LPR symptoms.
FAU - Reichel, Oliver
AU  - Reichel O
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Ludwig Maximilians 
      University, Munich, Germany. Oliver.Reichel@med.uni-muenchen.de
FAU - Dressel, Holger
AU  - Dressel H
FAU - Wiederanders, Katrin
AU  - Wiederanders K
FAU - Issing, Wolfgang J
AU  - Issing WJ
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
CIN - Z Gastroenterol. 2008 Dec;46(12):1404-5. PMID: 19053010
MH  - Adult
MH  - Aged
MH  - Anti-Ulcer Agents/administration & dosage/*therapeutic use
MH  - Double-Blind Method
MH  - Esomeprazole/administration & dosage/*therapeutic use
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy
MH  - Humans
MH  - Hypertrophy
MH  - Hypopharynx/drug effects/pathology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/administration & dosage/*therapeutic use
EDAT- 2008/08/30 09:00
MHDA- 2008/10/10 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/04/09 00:00 [received]
PHST- 2008/05/27 00:00 [revised]
PHST- 2008/06/03 00:00 [accepted]
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2008/10/10 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - S0194-5998(08)01072-3 [pii]
AID - 10.1016/j.otohns.2008.06.003 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2008 Sep;139(3):414-20. doi: 
      10.1016/j.otohns.2008.06.003.