PMID- 18723319
OWN - NLM
STAT- MEDLINE
DCOM- 20090109
LR  - 20161124
IS  - 1097-6795 (Electronic)
IS  - 0894-7317 (Linking)
VI  - 21
IP  - 10
DP  - 2008 Oct
TI  - Usefulness of dobutamine stress echocardiography with Tissue Doppler imaging for 
      the evaluation and follow-up of patients with repaired tetralogy of Fallot.
PG  - 1093-8
LID - 10.1016/j.echo.2008.06.010 [doi]
AB  - BACKGROUND: The longstanding pulmonary regurgitation in patients with repaired 
      tetralogy of Fallot (RTOF) results in right ventricular (RV) failure. The 
      estimation of RV function and reserve in these patients is of great importance, 
      especially for the determination of the proper timing of pulmonary valve 
      replacement. Tissue Doppler imaging (TDI) of the tricuspid annulus has been 
      proved a valuable tool in the evaluation of these patients. Dobutamine stress 
      echocardiography (DSE) in low doses detects the contractility reserve of cardiac 
      myocytes. The aim of our study was to estimate RV reserve in patients with RTOF 
      with the use of DSE and TDI and to examine whether this is related to baseline 
      TDI indices of the tricuspid annulus. METHODS: We studied 21 patients with RTOF 
      and 21 age- and gender-matched controls with TDI Doppler at the tricuspid annulus 
      during DSE. TDI measurements were made at baseline and at infusion rates of 10 
      and 20 microg x kg x min. RESULTS: Patients with RTOF had lower values of TDI 
      indices at baseline and during dobutamine infusion and smaller dobutamine-induced 
      increase of Sa (DeltaSa) (3.8 +/- 1.2 vs. 10.8 +/- 3.6 cm/sec, P < .001) and Aa 
      (3.5 +/- 2.2 vs. 10.0 +/- 3.2 cm/sec, P < .001). A value of DeltaSa < or = 6 
      cm/sec clearly discriminated patients from controls and could be predicted by 
      values of Sa < 11.5 cm/sec with sensitivity of 95% and specificity of 100%. 
      CONCLUSIONS: In patients with RTOF, impaired RV contractile reserve can be 
      documented with TDI of tricuspid annular motion during DSE and is predicted by 
      TDI indices at rest. Its serial estimation may contribute to optimal timing of 
      reoperation.
FAU - Brili, Stella
AU  - Brili S
AD  - First Department of Cardiology, Athens Medical School, Hippokratio Hospital, 
      Athens, Greece.
FAU - Stamatopoulos, Ilias
AU  - Stamatopoulos I
FAU - Barbetseas, John
AU  - Barbetseas J
FAU - Chrysohoou, Christina
AU  - Chrysohoou C
FAU - Alexopoulos, Nikolaos
AU  - Alexopoulos N
FAU - Misailidou, Maria
AU  - Misailidou M
FAU - Bratsas, Athanasios
AU  - Bratsas A
FAU - Stefanadis, Christodoulos
AU  - Stefanadis C
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20080823
PL  - United States
TA  - J Am Soc Echocardiogr
JT  - Journal of the American Society of Echocardiography : official publication of the 
      American Society of Echocardiography
JID - 8801388
RN  - 0 (Adrenergic beta-Agonists)
RN  - 3S12J47372 (Dobutamine)
SB  - IM
MH  - Adrenergic beta-Agonists
MH  - Adult
MH  - *Dobutamine
MH  - Echocardiography, Doppler/*methods
MH  - Exercise Test
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tetralogy of Fallot/*diagnostic imaging/*surgery
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2008/08/30 09:00
MHDA- 2009/01/10 09:00
CRDT- 2008/08/30 09:00
PHST- 2007/12/06 00:00 [received]
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2009/01/10 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - S0894-7317(08)00365-9 [pii]
AID - 10.1016/j.echo.2008.06.010 [doi]
PST - ppublish
SO  - J Am Soc Echocardiogr. 2008 Oct;21(10):1093-8. doi: 10.1016/j.echo.2008.06.010. 
      Epub 2008 Aug 23.