PMID- 18723429
OWN - NLM
STAT- MEDLINE
DCOM- 20081125
LR  - 20220317
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 112
IP  - 10
DP  - 2008 Nov 15
TI  - Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of 
      unrelated donor umbilical cord blood transplantation in pediatric patients with 
      hematologic malignancies.
PG  - 4318-27
LID - 10.1182/blood-2007-06-098020 [doi]
AB  - Outcomes of unrelated donor cord blood transplantation in 191 hematologic 
      malignancy children (median age, 7.7 years; median weight, 25.9 kg) enrolled 
      between 1999 and 2003 were studied (median follow-up, 27.4 months) in a 
      prospective phase 2 multicenter trial. Human leukocyte antigen (HLA) matching at 
      enrollment was 6/6 (n = 17), 5/6 (n = 58), 4/6 (n = 111), or 3/6 (n = 5) by 
      low-resolution HLA-A, -B, and high-resolution (HR) DRB1. Retrospectively, 179 
      pairs were HLA typed by HR. The median precryopreservation total nucleated cell 
      (TNC) dose was 5.1 x 10(7) TNC/kg (range, 1.5-23.7) with 3.9 x 10(7) TNC/kg 
      (range, 0.8-22.8) infused. The median time to engraftment (absolute neutrophil 
      count > 500/mm(3) and platelets 50 000/muL) was 27 and 174 days. The cumulative 
      incidence of neutrophil engraftment by day 42 was 79.9% (95% confidence interval 
      [CI], 75.1%-85.2%); acute grades III/IV GVHD by day 100 was 19.5% (95% CI, 
      13.9%-25.5%); and chronic GVHD at 2 years was 20.8% (95% CI, 14.8%-27.7%). HR 
      matching decreased the probability of severe acute GVHD. The cumulative incidence 
      of relapse at 2 years was 19.9% (95% CI, 14.8%-25.7%). The probabilities of 
      6-month and 2-year survivals were 67.4% and 49.5%. Unrelated donor cord blood 
      transplantation from partially HLA-mismatched units can cure many children with 
      leukemias. The study was registered at www.clinicaltrials.gov as #NCT00000603.
FAU - Kurtzberg, Joanne
AU  - Kurtzberg J
AD  - Duke University Medical Center, Durham, NC, USA. kurtz001@mc.duke.edu
FAU - Prasad, Vinod K
AU  - Prasad VK
FAU - Carter, Shelly L
AU  - Carter SL
FAU - Wagner, John E
AU  - Wagner JE
FAU - Baxter-Lowe, Lee Ann
AU  - Baxter-Lowe LA
FAU - Wall, Donna
AU  - Wall D
FAU - Kapoor, Neena
AU  - Kapoor N
FAU - Guinan, Eva C
AU  - Guinan EC
FAU - Feig, Stephen A
AU  - Feig SA
FAU - Wagner, Elizabeth L
AU  - Wagner EL
FAU - Kernan, Nancy A
AU  - Kernan NA
CN  - COBLT Steering Committee
LA  - eng
SI  - ClinicalTrials.gov/NCT00000603
GR  - N01HB67135/HL/NHLBI NIH HHS/United States
GR  - N01HB67139/HL/NHLBI NIH HHS/United States
GR  - N01-HB 67139/HB/NHLBI NIH HHS/United States
GR  - N01-HB 67135/HB/NHLBI NIH HHS/United States
GR  - N01HB67132/HL/NHLBI NIH HHS/United States
GR  - N01HB67138/HL/NHLBI NIH HHS/United States
GR  - N01-HB-67132/HB/NHLBI NIH HHS/United States
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20080821
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - *Cord Blood Stem Cell Transplantation
MH  - Disease-Free Survival
MH  - Female
MH  - *Graft Survival
MH  - Graft vs Host Disease/blood/*mortality
MH  - HLA Antigens/blood
MH  - Hematologic Neoplasms/blood/*mortality/*therapy
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Infant
MH  - Leukocyte Count/methods
MH  - Male
MH  - Platelet Count/methods
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Time Factors
MH  - Transplantation, Homologous
PMC - PMC2581998
EDAT- 2008/08/30 09:00
MHDA- 2008/12/17 09:00
PMCR- 2009/11/15
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
PHST- 2009/11/15 00:00 [pmc-release]
AID - S0006-4971(20)51890-9 [pii]
AID - 2007/098020 [pii]
AID - 10.1182/blood-2007-06-098020 [doi]
PST - ppublish
SO  - Blood. 2008 Nov 15;112(10):4318-27. doi: 10.1182/blood-2007-06-098020. Epub 2008 
      Aug 21.