PMID- 18724020 OWN - NLM STAT- MEDLINE DCOM- 20090818 LR - 20190819 IS - 1346-9843 (Print) IS - 1346-9843 (Linking) VI - 72 IP - 9 DP - 2008 Sep TI - Extent of late gadolinium enhancement in cardiovascular magnetic resonance and its relation with left ventricular diastolic function in patients with hypertrophic cardiomyopathy. PG - 1449-53 AB - BACKGROUND: The aim of this study was to determine whether the extent of late gadolinium enhancement (LGE) is associated with left ventricular (LV) function in patients with hypertrophic cardiomyopathy (HCM). METHODS AND RESULTS: Forty-seven patients with HCM (35 males, mean age 53+/-14, 14 with LV outflow tract obstruction) underwent cardiovascular magnetic resonance imaging and comprehensive echocardiographic examination. The extent of LGE was expressed as LGE volume and LGE percentage of LV volume. LGE was present in 40 (85.1%) of 47 patients. The mean LGE volume was 36.5+/-36 cm3, and the mean percentage of LV volume was 16.4+/-17%. Following adjustment for age, mitral regurgitation and LV mass index, LGE volume and percentage positively correlated with the left atrial volume index (r=0.388, p=0.009 and r=0.425, p=0.004, respectively). However, there was no significant association of functional class, ejection fraction, mitral flow, or annular velocities with the extent of LGE. CONCLUSIONS: In HCM patients, the extent of LGE positively correlated with the left atrial volume index, a surrogate marker of chronic diastolic burden. These findings suggest that myocardial scarring may be a pathologic substrate for chronic diastolic dysfunction in patients with HCM. FAU - Choi, Dae-Sik AU - Choi DS AD - Division of Cardiology, Yonsei University College of Medicine, Seoul, Korea. FAU - Ha, Jong-Won AU - Ha JW FAU - Choi, Byoungwook AU - Choi B FAU - Yang, Woo-In AU - Yang WI FAU - Choi, Eui-Young AU - Choi EY FAU - Rim, Se-Joong AU - Rim SJ FAU - Chung, Namsik AU - Chung N LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Japan TA - Circ J JT - Circulation journal : official journal of the Japanese Circulation Society JID - 101137683 RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Adult MH - Age Factors MH - Aged MH - Cardiomyopathy, Hypertrophic/diagnostic imaging/*physiopathology MH - *Diastole MH - *Gadolinium MH - Humans MH - Magnetic Resonance Imaging/*methods MH - Male MH - Middle Aged MH - Mitral Valve/diagnostic imaging/physiopathology MH - Mitral Valve Insufficiency/diagnostic imaging/physiopathology MH - Radiography MH - *Stroke Volume MH - *Ventricular Function, Left EDAT- 2008/08/30 09:00 MHDA- 2009/08/19 09:00 CRDT- 2008/08/30 09:00 PHST- 2008/08/30 09:00 [pubmed] PHST- 2009/08/19 09:00 [medline] PHST- 2008/08/30 09:00 [entrez] AID - JST.JSTAGE/circj/CJ-07-0874 [pii] AID - 10.1253/circj.cj-07-0874 [doi] PST - ppublish SO - Circ J. 2008 Sep;72(9):1449-53. doi: 10.1253/circj.cj-07-0874.