PMID- 18724649
OWN - NLM
STAT- MEDLINE
DCOM- 20081202
LR  - 20131121
IS  - 1545-9616 (Print)
IS  - 1545-9616 (Linking)
VI  - 7
IP  - 8 Suppl
DP  - 2008 Aug
TI  - Tretinoin microsphere gel in younger acne patients.
PG  - s9-13
AB  - BACKGROUND: Facial acne is common in adolescents and can have a significant 
      psychosocial impact. Treatments prescribed should not add stress by causing 
      excessive localized irritation. OBJECTIVE: To determine whether the lowest 
      concentration of tretinoin microsphere gel (TMG) currently available (0.04%) 
      provides an acceptable balance of efficacy and tolerability for adolescents with 
      moderate facial acne. METHODS: The findings of 2 multicenter, randomized, 
      double-blind, vehicle-controlled trials of TMG 0.04% applied once nightly for 12 
      weeks in 245 adolescents ages 11 to 16 years with moderate facial acne were 
      combined. Patients were evaluated via changes in acne lesion counts and the 
      occurrence of cutaneous and other adverse effects. RESULTS: Tretinoin microsphere 
      gel 0.04% reduced total, noninflammatory, and inflammatory lesion counts to a 
      significantly greater extent than the vehicle gel at 12 weeks (P<.000005). The 
      mean percentage reductions in noninflammatory and inflammatory lesion counts at 
      12 weeks in females were 45.0% and 51.4%, respectively; and in males, 20.5% and 
      36.7%, respectively. Tretinoin microsphere gel 0.04% was tolerated well, with 
      over 70% of patients experiencing no cutaneous adverse events (AEs). CONCLUSION: 
      Tretinoin microsphere gel 0.04% is effective in significantly reducing all types 
      of acne lesions in adolescents with moderate facial acne ages 11 to 16 years, and 
      has a low incidence of cutaneous AEs.
FAU - Jorizzo, Joseph
AU  - Jorizzo J
AD  - Department of Dermatology, Wake Forest University School of Medicine, 
      Winston-Salem, NC, USA.
FAU - Grossman, Rachel
AU  - Grossman R
FAU - Nighland, Marge
AU  - Nighland M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Drugs Dermatol
JT  - Journal of drugs in dermatology : JDD
JID - 101160020
RN  - 0 (Gels)
RN  - 0 (Keratolytic Agents)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Acne Vulgaris/*drug therapy
MH  - Adolescent
MH  - Female
MH  - Gels
MH  - Humans
MH  - Keratolytic Agents/*therapeutic use
MH  - Male
MH  - Microspheres
MH  - Randomized Controlled Trials as Topic
MH  - Tretinoin/administration & dosage/adverse effects/*therapeutic use
EDAT- 2008/08/30 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
PST - ppublish
SO  - J Drugs Dermatol. 2008 Aug;7(8 Suppl):s9-13.