PMID- 18724934
OWN - NLM
STAT- MEDLINE
DCOM- 20080910
LR  - 20230425
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 134
IP  - 4
DP  - 2008 Aug 22
TI  - The regulation and evolution of a genetic switch controlling sexually dimorphic 
      traits in Drosophila.
PG  - 610-23
LID - 10.1016/j.cell.2008.06.052 [doi]
AB  - Sexually dimorphic traits play key roles in animal evolution and behavior. Little 
      is known, however, about the mechanisms governing their development and 
      evolution. One recently evolved dimorphic trait is the male-specific abdominal 
      pigmentation of Drosophila melanogaster, which is repressed in females by the 
      Bric-a-brac (Bab) proteins. To understand the regulation and origin of this 
      trait, we have identified and traced the evolution of the genetic switch 
      controlling dimorphic bab expression. We show that the HOX protein Abdominal-B 
      (ABD-B) and the sex-specific isoforms of Doublesex (DSX) directly regulate a bab 
      cis-regulatory element (CRE). In females, ABD-B and DSX(F) activate bab 
      expression whereas in males DSX(M) directly represses bab, which allows for 
      pigmentation. A new domain of dimorphic bab expression evolved through multiple 
      fine-scale changes within this CRE, whose ancestral role was to regulate other 
      dimorphic features. These findings reveal how new dimorphic characters can emerge 
      from genetic networks regulating pre-existing dimorphic traits.
FAU - Williams, Thomas M
AU  - Williams TM
AD  - Howard Hughes Medical Institute and Laboratory of Molecular Biology, University 
      of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA.
FAU - Selegue, Jane E
AU  - Selegue JE
FAU - Werner, Thomas
AU  - Werner T
FAU - Gompel, Nicolas
AU  - Gompel N
FAU - Kopp, Artyom
AU  - Kopp A
FAU - Carroll, Sean B
AU  - Carroll SB
LA  - eng
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - F32 GM076935/GM/NIGMS NIH HHS/United States
GR  - GM076935/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Abd-B proteins, Drosophila)
RN  - 0 (Bric-a-brac protein 1, Drosophila)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (DSX protein, Drosophila)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - DNA-Binding Proteins/metabolism
MH  - Drosophila Proteins/metabolism
MH  - Drosophila melanogaster/*genetics/physiology
MH  - *Evolution, Molecular
MH  - Female
MH  - *Gene Expression Regulation
MH  - Homeodomain Proteins/metabolism
MH  - Male
MH  - *Sex Characteristics
MH  - Transcription Factors/metabolism
PMC - PMC2597198
MID - NIHMS67751
OID - NLM: HHMIMS67751
EDAT- 2008/08/30 09:00
MHDA- 2008/09/11 09:00
PMCR- 2009/02/22
CRDT- 2008/08/30 09:00
PHST- 2008/04/24 00:00 [received]
PHST- 2008/06/16 00:00 [revised]
PHST- 2008/06/25 00:00 [accepted]
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2008/09/11 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
PHST- 2009/02/22 00:00 [pmc-release]
AID - S0092-8674(08)00840-4 [pii]
AID - 10.1016/j.cell.2008.06.052 [doi]
PST - ppublish
SO  - Cell. 2008 Aug 22;134(4):610-23. doi: 10.1016/j.cell.2008.06.052.