PMID- 18725430
OWN - NLM
STAT- MEDLINE
DCOM- 20090113
LR  - 20211020
IS  - 1534-7796 (Electronic)
IS  - 0033-3174 (Print)
IS  - 0033-3174 (Linking)
VI  - 70
IP  - 7
DP  - 2008 Sep
TI  - Nighttime heart rate and survival in depressed patients post acute myocardial 
      infarction.
PG  - 757-63
LID - 10.1097/PSY.0b013e3181835ca3 [doi]
AB  - OBJECTIVES: To determine if: 1) depressed patients with a recent acute myocardial 
      infarction (AMI) have higher nighttime heart rate (HR) than nondepressed 
      patients, and 2) elevated nighttime HR is associated with decreased survival post 
      AMI. Depression is a risk factor for mortality post AMI. It is also associated 
      with sleep disturbances and with elevated HR, which may be more pronounced at 
      night. Resting and 24-hour HR have been found to predict mortality in patient and 
      community samples. METHODS: Ambulatory electrocardiographic data were obtained 
      from 333 depressed patients and 383 nondepressed patients with recent AMI. They 
      were followed for up to 30 months (median = 24 months). RESULTS: Depressed 
      patients had higher nighttime HR (70.7 +/- 0.7 versus 67.7 +/- 0.6 beats per 
      minute (bpm); p = .001), and daytime HR (76.4 +/- 0.7 versus 74.2 +/- 0.6 bpm; p 
      = .02) than nondepressed patients, even after adjusting for potential confounds. 
      Depression (hazard ratio (Haz R) = 2.19; p = .02) and nighttime HR (Haz R = 1.03; 
      p = .004), but not daytime HR, predicted survival after adjusting for other major 
      predictors and for each other. The interaction between nighttime HR and 
      depression on survival approached, but did not achieve, significance (p = .08). 
      CONCLUSIONS: Mean day and nighttime HR values are higher in depressed patients 
      than in nondepressed patients post AMI. Depression and elevated nighttime HR, but 
      not daytime HR, are independent predictors of survival in these patients. 
      Although depressed patients have a higher nighttime HR than nondepressed 
      patients, nighttime HR predicts mortality in both depressed and nondepressed 
      patients.
FAU - Carney, Robert M
AU  - Carney RM
AD  - Departments of Psychiatry, Washington University School of Medicine, St. Louis, 
      MO 63110, USA. carneyr@bmc.wustl.edu
FAU - Steinmeyer, Brian
AU  - Steinmeyer B
FAU - Freedland, Kenneth E
AU  - Freedland KE
FAU - Blumenthal, James A
AU  - Blumenthal JA
FAU - Stein, Phyllis K
AU  - Stein PK
FAU - Steinhoff, William A
AU  - Steinhoff WA
FAU - Howells, William B
AU  - Howells WB
FAU - Berkman, Lisa F
AU  - Berkman LF
FAU - Watkins, Lana L
AU  - Watkins LL
FAU - Czajkowski, Susan M
AU  - Czajkowski SM
FAU - Domitrovich, Peter P
AU  - Domitrovich PP
FAU - Burg, Matthew M
AU  - Burg MM
FAU - Hayano, Junichiro
AU  - Hayano J
FAU - Jaffe, Allan S
AU  - Jaffe AS
LA  - eng
GR  - R01 HL058946/HL/NHLBI NIH HHS/United States
GR  - R0-1HL58946/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080825
PL  - United States
TA  - Psychosom Med
JT  - Psychosomatic medicine
JID - 0376505
SB  - IM
MH  - Acute Disease
MH  - *Circadian Rhythm
MH  - Depressive Disorder/*epidemiology/*physiopathology
MH  - Electrocardiography, Ambulatory/statistics & numerical data
MH  - Female
MH  - Follow-Up Studies
MH  - *Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*epidemiology/*physiopathology
MH  - Predictive Value of Tests
MH  - Risk Factors
MH  - Survival Analysis
MH  - United States/epidemiology
PMC - PMC3561711
MID - NIHMS436956
EDAT- 2008/08/30 09:00
MHDA- 2009/01/14 09:00
PMCR- 2013/02/01
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2009/01/14 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
PHST- 2013/02/01 00:00 [pmc-release]
AID - PSY.0b013e3181835ca3 [pii]
AID - 10.1097/PSY.0b013e3181835ca3 [doi]
PST - ppublish
SO  - Psychosom Med. 2008 Sep;70(7):757-63. doi: 10.1097/PSY.0b013e3181835ca3. Epub 
      2008 Aug 25.