PMID- 18726871
OWN - NLM
STAT- MEDLINE
DCOM- 20100624
LR  - 20100315
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 118
IP  - 3
DP  - 2010 Mar
TI  - Vaspin (SERPINA12) genotypes and risk of type 2 diabetes: Results from the 
      MONICA/KORA studies.
PG  - 184-9
LID - 10.1055/s-2008-1081499 [doi]
AB  - Vaspin has recently been identified as novel adipokine with high expression in 
      adipose tissue of obese and type 2 diabetic subjects and with potentially 
      insulin-sensitising properties. However, the impact of vaspin gene variants on 
      the risk of type 2 diabetes mellitus (T2DM) has not been determined yet. 
      Therefore, the aim of our study was to investigate the association of vaspin 
      single nucleotide polymorphisms (SNPs) with T2DM and obesity. We analysed the 
      association between 25 vaspin SNPs and T2DM in initially healthy 35-84 year-old 
      individuals of the population-based, cross-sectional German KORA F3 study and 
      assessed the association with measures of obesity. Genotyping was carried out 
      with matrix-assisted laser desorption/ionisation-time of flight mass spectrometry 
      of allele-dependent primer extension products and associations with T2DM and 
      obesity were analysed by logistic regression analysis. Our results demonstrate a 
      significant association of vaspin SNP rs2236242 with T2DM in the KORA F3 study 
      with the AA genotype bearing an increased risk (adjusted OR 2.35 [1.59; 3.46] 
      versus AT/TT). This association appears to be independent of obesity. Our finding 
      corroborates previous studies that suggested a link between the novel adipokine 
      vaspin and glucose metabolism.
CI  - J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart * New York.
FAU - Kempf, K
AU  - Kempf K
AD  - Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz 
      Institute for Diabetes Research at Heinrich Heine University Dusseldorf, Germany.
FAU - Rose, B
AU  - Rose B
FAU - Illig, T
AU  - Illig T
FAU - Rathmann, W
AU  - Rathmann W
FAU - Strassburger, K
AU  - Strassburger K
FAU - Thorand, B
AU  - Thorand B
FAU - Meisinger, C
AU  - Meisinger C
FAU - Wichmann, H-E
AU  - Wichmann HE
FAU - Herder, C
AU  - Herder C
FAU - Vollmert, C
AU  - Vollmert C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080825
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (SERPINA12 protein, human)
RN  - 0 (Serpins)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/epidemiology/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Germany/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Serpins/*genetics
EDAT- 2008/08/30 09:00
MHDA- 2010/06/25 06:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2010/06/25 06:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - 10.1055/s-2008-1081499 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2010 Mar;118(3):184-9. doi: 10.1055/s-2008-1081499. 
      Epub 2008 Aug 25.