PMID- 18726989
OWN - NLM
STAT- MEDLINE
DCOM- 20090227
LR  - 20211020
IS  - 1098-2302 (Electronic)
IS  - 0012-1630 (Print)
IS  - 0012-1630 (Linking)
VI  - 50
IP  - 7
DP  - 2008 Nov
TI  - Cross-modal transfer of the conditioned eyeblink response during interstimulus 
      interval discrimination training in young rats.
PG  - 647-64
LID - 10.1002/dev.20335 [doi]
AB  - Eyeblink classical conditioning (EBC) was observed across a broad developmental 
      period with tasks utilizing two interstimulus intervals (ISIs). In ISI 
      discrimination, two distinct conditioned stimuli (CSs; light and tone) are 
      reinforced with a periocular shock unconditioned stimulus (US) at two different 
      CS-US intervals. Temporal uncertainty is identical in design with the exception 
      that the same CS is presented at both intervals. Developmental changes in 
      conditioning have been reported in each task beyond ages when single-ISI learning 
      is well developed. The present study sought to replicate and extend these 
      previous findings by testing each task at four separate ages. Consistent with 
      previous findings, younger rats (postnatal day--PD23 and 30) trained in ISI 
      discrimination showed evidence of enhanced cross-modal influence of the short 
      CS-US pairing upon long CS conditioning relative to older subjects. ISI 
      discrimination training at PD43-47 yielded outcomes similar to those in adults 
      (PD65-71). Cross-modal transfer effects in this task therefore appear to diminish 
      between PD30 and PD43-47. Comparisons of ISI discrimination with temporal 
      uncertainty indicated that cross-modal transfer in ISI discrimination at the 
      youngest ages did not represent complete generalization across CSs. ISI 
      discrimination undergoes a more protracted developmental emergence than 
      single-cue EBC and may be a more sensitive indicator of developmental disorders 
      involving cerebellar dysfunction.
FAU - Brown, Kevin L
AU  - Brown KL
AD  - Department of Psychology University of Delaware, Newark, DE, USA. 
      kbrown@psych.udel.edu
FAU - Stanton, Mark E
AU  - Stanton ME
LA  - eng
GR  - 1-F31-AA16250-01/AA/NIAAA NIH HHS/United States
GR  - R01 AA014288-03/AA/NIAAA NIH HHS/United States
GR  - R01 AA014288/AA/NIAAA NIH HHS/United States
GR  - F31 AA016250/AA/NIAAA NIH HHS/United States
GR  - F31 AA016250-01/AA/NIAAA NIH HHS/United States
GR  - R01 AA011945/AA/NIAAA NIH HHS/United States
GR  - 1-R01-AA11945/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Dev Psychobiol
JT  - Developmental psychobiology
JID - 0164074
SB  - IM
MH  - Acoustic Stimulation
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - *Auditory Perception
MH  - *Conditioning, Eyelid
MH  - *Discrimination Learning
MH  - Electroshock
MH  - Female
MH  - Male
MH  - Photic Stimulation
MH  - Rats
MH  - Rats, Long-Evans
MH  - Reaction Time
MH  - *Time Perception
MH  - *Transfer, Psychology
MH  - Uncertainty
MH  - *Visual Perception
PMC - PMC2583358
MID - NIHMS76098
EDAT- 2008/08/30 09:00
MHDA- 2009/02/28 09:00
PMCR- 2009/11/01
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2009/02/28 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
PHST- 2009/11/01 00:00 [pmc-release]
AID - 10.1002/dev.20335 [doi]
PST - ppublish
SO  - Dev Psychobiol. 2008 Nov;50(7):647-64. doi: 10.1002/dev.20335.