PMID- 18727110
OWN - NLM
STAT- MEDLINE
DCOM- 20100301
LR  - 20211020
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 32
IP  - 6
DP  - 2009 Jun
TI  - Carbon-coated stents in patients with acute coronary syndromes.
PG  - E1-6
LID - 10.1002/clc.20295 [doi]
AB  - BACKGROUND: For patients with ST elevation myocardial infarction (STEMI) or 
      non-ST elevation myocardial infarction (NSTEMI), rapid restoration of coronary 
      blood flow is the primary therapeutic goal. Because of the acute nature of this 
      clinical presentation, bleeding risks may not be adequately evaluated, limiting 
      the use of drug-eluting stents, since premature discontinuation of antiplatelet 
      therapy strongly predicts stent thrombosis. We evaluated angiographic and 
      clinical results of non-drug-eluting carbon-coated stents. METHODS: In this 
      prospective observational study, angiographic and clinical 6-mo results of a 
      carbon-coated stent for treatment of acute lesions in native coronary arteries 
      were evaluated. Angiographic main outcome measures included in-stent late loss 
      and binary restenosis rate. Major adverse cardiac events (MACEs) were defined as 
      any death, Q-wave myocardial infarction (MI), and target lesion 
      revascularization. RESULTS: We included 320 patients with STEMI (n = 205) or 
      NSTEMI (n = 115) with 360 lesions. Reference vessel diameter was 2.93 +/- 0.53 mm 
      and stented length 22.7 +/- 13.8 mm. Angiographic follow-up was available in 220 
      of 360 lesions (61%). In-stent late loss was 0.69 +/- 0.75 mm, with a binary 
      restenosis rate of 19.1%. For the total segment late loss was 0.74 +/- 0.77 mm 
      and binary restenosis rate 21.4%. Clinical follow-up for 97.4% of discharged 
      patients was available. Hierarchical MACEs were death in 14 patients (4.4%), 
      Q-wave MI in 3 patients (0.9%), and target lesion revascularization in 39 
      patients (12.2%). CONCLUSION: In this prospective, observational study, the use 
      of a carbon-coated stent for treatment of lesions in patients with STEMI or 
      NSTEMI was associated with a low late loss, translating into a low binary 
      angiographic restenosis rate within a 6-mo follow-up.
CI  - 2008 Wiley Periodicals, Inc.
FAU - Wohrle, Jochen
AU  - Wohrle J
AD  - Department of Internal Medicine II, University of Ulm, Ulm, Germany. 
      jochen.woehrle@uniklinik-ulm.de
FAU - Nusser, Thorsten
AU  - Nusser T
FAU - Langenwalder, Simone
AU  - Langenwalder S
FAU - Heombach, Vinzenz
AU  - Heombach V
FAU - Kochs, Matthias
AU  - Kochs M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Coated Materials, Biocompatible)
RN  - 7440-44-0 (Carbon)
SB  - IM
MH  - Acute Coronary Syndrome/complications/diagnostic imaging/mortality/*therapy
MH  - Aged
MH  - Angioplasty, Balloon, Coronary/adverse effects/*instrumentation/mortality
MH  - *Carbon
MH  - *Coated Materials, Biocompatible
MH  - Coronary Angiography
MH  - Coronary Restenosis/etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnostic imaging/etiology/mortality/*therapy
MH  - Prospective Studies
MH  - Prosthesis Design
MH  - *Stents
MH  - Thrombosis/etiology
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC6652969
EDAT- 2008/08/30 09:00
MHDA- 2010/03/02 06:00
PMCR- 2008/08/25
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2010/03/02 06:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
PHST- 2008/08/25 00:00 [pmc-release]
AID - CLC20295 [pii]
AID - 10.1002/clc.20295 [doi]
PST - ppublish
SO  - Clin Cardiol. 2009 Jun;32(6):E1-6. doi: 10.1002/clc.20295.