PMID- 18727650
OWN - NLM
STAT- MEDLINE
DCOM- 20081218
LR  - 20151119
IS  - 1468-2982 (Electronic)
IS  - 0333-1024 (Linking)
VI  - 28
IP  - 10
DP  - 2008 Oct
TI  - Tolerability of acute migraine medications: influence of methods of assessment 
      and relationship with headache attributes.
PG  - 1012-6
LID - 10.1111/j.1468-2982.2008.01643.x [doi]
AB  - Tolerability is an important attribute of patient satisfaction with, and 
      consequence adherence to, migraine acute treatment. Nevertheless, the 
      determinants of tolerability are poorly explored. Accordingly, our objectives 
      were: (i) in subjects receiving triptans, to contrast two methods of assessing 
      adverse events (AEs); and (ii) to explore the relationship between migraine 
      features and treatment attributes with tolerability. We surveyed 365 migraineurs 
      who had been using the same triptan for at least 3 months. After prospectively 
      treating an attack, headache characteristics and treatment response were assessed 
      using headache calendars. Subjects also completed a standardized questionnaire, 
      first asking about any AE and then prompting patients with a list of possible 
      AEs. We contrasted both sets of answers and conducted logistic regression to 
      assess if headache attributes or response to therapy influenced tolerability. 
      Using the unprompted method, AEs occurred in 11.5-36.4% of patients, depending on 
      the triptan used. Using the prompted method, they ranged from 26.9 to 64.3%. 
      Chest and neck tightness were spontaneously reported by 3.5% of the sample, vs. 
      7.4% when prompted (P < 0.05). Chest pain was not spontaneously reported and was 
      elicited in nine patients (2.5%, P = 0.002). Feeling groggy occurred in 5.7 and 
      17.5% (P < 0.001). AEs were not a function of headache severity, disability, 
      efficacy of the drug, time to meaningful relief with the drug or recurrence of 
      pain. The report of AEs varies dramatically with the methods of assessment. 
      However, tolerability is not influenced by the severity of the attacks or by 
      medication efficacy.
FAU - Feleppa, M
AU  - Feleppa M
AD  - Department of Neurology, Hospital 'G. Rummo', Benevento, Italy. 
      michele.feleppa@ao-rummo.it
FAU - Apice, G
AU  - Apice G
FAU - D'Alessio, A
AU  - D'Alessio A
FAU - Fucci, S
AU  - Fucci S
FAU - Bigal, M E
AU  - Bigal ME
LA  - eng
PT  - Journal Article
DEP - 20080822
PL  - England
TA  - Cephalalgia
JT  - Cephalalgia : an international journal of headache
JID - 8200710
RN  - 0 (Serotonin Receptor Agonists)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Adverse Drug Reaction Reporting Systems/*statistics & numerical data
MH  - Data Collection
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Medical Records
MH  - Migraine Disorders/*drug therapy
MH  - Prospective Studies
MH  - Serotonin Receptor Agonists/administration & dosage/*adverse effects
MH  - Severity of Illness Index
MH  - *Surveys and Questionnaires
EDAT- 2008/08/30 09:00
MHDA- 2008/12/19 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2008/12/19 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - CHA1643 [pii]
AID - 10.1111/j.1468-2982.2008.01643.x [doi]
PST - ppublish
SO  - Cephalalgia. 2008 Oct;28(10):1012-6. doi: 10.1111/j.1468-2982.2008.01643.x. Epub 
      2008 Aug 22.