PMID- 18727928
OWN - NLM
STAT- MEDLINE
DCOM- 20090112
LR  - 20131121
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 596
IP  - 1-3
DP  - 2008 Oct 31
TI  - A new brain area affected by 3,4-methylenedioxymethamphetamine: A 
      microdialysis-biotelemetry study.
PG  - 84-8
LID - 10.1016/j.ejphar.2008.08.001 [doi]
AB  - The widespread abuse of 3,4-methylenedioxymethamphetamine (MDMA) has intensified 
      the need to learn more about this drug (e.g. its effects, its mechanism of 
      action, brain areas affected). MDMA-induced hyperthermia is a severe 
      physiological event not only because it can produce severe adverse consequences 
      in human as well as experimental animals, but also because it plays a major role 
      in determining the severity of the long-term MDMA-induced neurotoxicity that 
      occurs. However, the effects of MDMA on the preoptic anterior hypothalamus, the 
      main brain area responsible for control of body temperature, are still unknown. 
      In vivo microdialysis-biotelemetry and pharmacological testing were used to 
      determine whether the preoptic anterior hypothalamus is among the brain areas 
      affected by MDMA by investigating the role of the dopamine neurotransmitter 
      system. We examined the effect of a hyperthermic dose of MDMA on the 
      extracellular level of dopamine in the preoptic anterior hypothalamus, and 
      whether this effect is related to the acute hyperthermic response. The 
      administration of a hyperthermic dose of MDMA (20 mg/kg) is accompanied by an 
      increase in the extracellular level of dopamine in the preoptic anterior 
      hypothalamus. Both the hyperthermia and augmented level of dopamine in the 
      preoptic anterior hypothalamus after intraperitoneal injection of MDMA were 
      significantly reduced by the pretreatment with D(1)-selective dopamine receptor 
      antagonist, 
      R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzapine (SCH 
      23390). These data provide the first in vivo evidence that the effects of MDMA 
      extend to preoptic anterior hypothalamus.
FAU - Benamar, Khalid
AU  - Benamar K
AD  - Center for Substance Abuse Research, Temple University School of Medicine, 
      Philadelphia, PA 19140, USA. kbenamar@temple.edu
FAU - Geller, Ellen B
AU  - Geller EB
FAU - Adler, Martin W
AU  - Adler MW
LA  - eng
GR  - DA 06650/DA/NIDA NIH HHS/United States
GR  - DA 13429/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080813
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Central Nervous System Agents)
RN  - 0 (Receptors, Dopamine D1)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Brain/anatomy & histology/*drug effects/metabolism
MH  - Central Nervous System Agents/*pharmacology
MH  - Dopamine/metabolism
MH  - Extracellular Space/metabolism
MH  - Male
MH  - Microdialysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Preoptic Area/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D1/antagonists & inhibitors
MH  - Telemetry
EDAT- 2008/08/30 09:00
MHDA- 2009/01/13 09:00
CRDT- 2008/08/30 09:00
PHST- 2007/12/21 00:00 [received]
PHST- 2008/07/09 00:00 [revised]
PHST- 2008/08/04 00:00 [accepted]
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2009/01/13 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - S0014-2999(08)00857-1 [pii]
AID - 10.1016/j.ejphar.2008.08.001 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2008 Oct 31;596(1-3):84-8. doi: 10.1016/j.ejphar.2008.08.001. 
      Epub 2008 Aug 13.