PMID- 18728371
OWN - NLM
STAT- MEDLINE
DCOM- 20081006
LR  - 20151119
IS  - 1423-0232 (Electronic)
IS  - 0030-2414 (Linking)
VI  - 75
IP  - 1-2
DP  - 2008
TI  - Paclitaxel- and platinum-based postoperative chemotherapy for primary fallopian 
      tube carcinoma: a single institution experience.
PG  - 42-8
LID - 10.1159/000151668 [doi]
AB  - BACKGROUND: Primary fallopian tube carcinoma (PFTC) is a rare gynecologic 
      malignancy with very few data existing on the activity of the combination of 
      paclitaxel with a platinum analogue as adjuvant chemotherapy. METHODS: We 
      retrospectively analyzed 41 consecutive patients with PFTC who were treated 
      postoperatively with paclitaxel- and platinum-containing chemotherapy regimens. 
      RESULTS: We observed 12 (63.2%) complete and 6 (31.6%) partial responses among 19 
      patients with measurable disease. The median time to disease progression (TTP) 
      for all patients was 68 months. The median overall survival (OS) for all patients 
      has not been reached yet. The median TTP was 84 months for patients with stage 
      I/II disease and 34 months for patients with advanced disease (p = 0.017). Median 
      OS has not been reached yet for patients with stage I/II PFTC, while it was 63.8 
      months for patients with stage III/IV disease (p = 0.002). Furthermore, OS has 
      not been reached yet for patients with optimally debulked tumors, while it was 
      34.1 months for patients with residual disease >2 cm (p < 0.0001). CONCLUSION: 
      Adjuvant platinum- and paclitaxel-based chemotherapy should be regarded as the 
      standard treatment in patients with PFTC. Early stage disease and optimal 
      debulking are associated with improved TTP and OS.
CI  - Copyright 2008 S. Karger AG, Basel.
FAU - Papadimitriou, Christos A
AU  - Papadimitriou CA
AD  - Department of Clinical Therapeutics, Alexandra Hospital, Athens, Greece. 
      chr_papadim@yahoo.gr
FAU - Peitsidis, Panagiotis
AU  - Peitsidis P
FAU - Bozas, George
AU  - Bozas G
FAU - Grimani, Irene
AU  - Grimani I
FAU - Vlahos, George
AU  - Vlahos G
FAU - Rodolakis, Alexandros
AU  - Rodolakis A
FAU - Lianos, Evangelos
AU  - Lianos E
FAU - Bamias, Aristotelis
AU  - Bamias A
FAU - Lainakis, George
AU  - Lainakis G
FAU - Dimopoulos, Meletios-A
AU  - Dimopoulos MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080826
PL  - Switzerland
TA  - Oncology
JT  - Oncology
JID - 0135054
RN  - 0 (Platinum Compounds)
RN  - P88XT4IS4D (Paclitaxel)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
MH  - Fallopian Tube Neoplasms/*drug therapy/pathology/surgery
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Paclitaxel/administration & dosage
MH  - Platinum Compounds/administration & dosage
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Treatment Outcome
EDAT- 2008/08/30 09:00
MHDA- 2008/10/07 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/03/03 00:00 [received]
PHST- 2008/04/12 00:00 [accepted]
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2008/10/07 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - 000151668 [pii]
AID - 10.1159/000151668 [doi]
PST - ppublish
SO  - Oncology. 2008;75(1-2):42-8. doi: 10.1159/000151668. Epub 2008 Aug 26.