PMID- 18728712
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1176-6336 (Print)
IS  - 1178-203X (Electronic)
IS  - 1176-6336 (Linking)
VI  - 4
IP  - 1
DP  - 2008 Feb
TI  - Management of laryngopharyngeal reflux with proton pump inhibitors.
PG  - 225-33
AB  - There is a lack of consistent guidelines and consensus for the diagnosis of 
      laryngopharyngeal reflux (LPR). A therapeutic trial with a proton pump inhibitor 
      (PPI) has been suggested to identify patients with LPR. This review focuses on 
      the current difficulties in diagnosing the disease and examines the evidence for 
      the effectiveness of PPI therapy in suspected reflux-related laryngeal symptoms. 
      Additionally, mode of action, safety, and tolerability of PPIs are described. A 
      total of 7 placebo-controlled trials were identified and included in the review. 
      All studies evaluated the effect of a PPI on symptoms and objective laryngoscopic 
      findings in suspected LPR. Data from these trials show that PPI therapy is no 
      more effective than placebo in producing symptom relief in patients suspected of 
      LPR. Symptoms, laryngoscopic findings, or abnormal findings on pH monitoring will 
      not predict response to PPI therapy. High placebo response levels suggest a much 
      more complex and multifactorial pathophysiology of LPR than simple acid reflux. 
      Further studies are needed to characterize subgroups of patients with 
      reflux-associated laryngeal symptoms that might benefit from treatment with PPI. 
      Future studies should use validated patient reported outcome measures with 
      endpoints that represent a predefined clinically meaningful change in symptom 
      scores.
FAU - Reimer, Christina
AU  - Reimer C
AD  - Department of Medical Gastroenterology, Koge University Hospital Denmark.
FAU - Bytzer, Peter
AU  - Bytzer P
LA  - eng
PT  - Journal Article
PL  - New Zealand
TA  - Ther Clin Risk Manag
JT  - Therapeutics and clinical risk management
JID - 101253281
PMC - PMC2503658
OTO - NOTNLM
OT  - proton pump inhibitor
OT  - laryngopharyngeal reflux
EDAT- 2008/08/30 09:00
MHDA- 2008/08/30 09:01
PMCR- 2008/06/01
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2008/08/30 09:01 [medline]
PHST- 2008/08/30 09:00 [entrez]
PHST- 2008/06/01 00:00 [pmc-release]
AID - 10.2147/tcrm.s6862 [doi]
PST - ppublish
SO  - Ther Clin Risk Manag. 2008 Feb;4(1):225-33. doi: 10.2147/tcrm.s6862.