PMID- 18729404
OWN - NLM
STAT- MEDLINE
DCOM- 20090123
LR  - 20161124
IS  - 1520-6106 (Print)
IS  - 1520-5207 (Linking)
VI  - 112
IP  - 46
DP  - 2008 Nov 20
TI  - Optimal design and characterization of superparamagnetic iron oxide nanoparticles 
      coated with polyvinyl alcohol for targeted delivery and imaging.
PG  - 14470-81
LID - 10.1021/jp803016n [doi]
AB  - Superparamagnetic iron oxide nanoparticles (SPION) with narrow size distribution 
      and stabilized by polyvinyl alcohol (PVA) were synthesized. The particles were 
      prepared by a coprecipitation technique using ferric and ferrous salts with a 
      molar Fe3+/Fe2+ ratio of 2. Using a design of experiments (DOE) approach, the 
      effect of different synthesis parameters (stirring rate and base molarity) on the 
      structure, morphology, saturation magnetization, purity, size, and size 
      distribution of the synthesized magnetite nanoparticles was studied by various 
      analysis techniques including X-ray powder diffraction (XRD), thermogravimetric 
      analysis (TGA) with differential scanning calorimetry (DSC) measurements, 
      vibrating-sample magnetometer (VSM), transmission electron microscopy (TEM), 
      UV-visible, and Fourier transform infrared (FT-IR) spectrometer. PVA not only 
      stabilized the colloid but also played a role in preventing further growth of 
      SPION followed by the formation of large agglomerates by chemisorption on the 
      surface of particles. A rich behavior in particle size, particle formation, and 
      super paramagnetic properties is observed as a function of molarity and stirring 
      conditions. The particle size and the magnetic properties as well as particle 
      shape and aggregation (individual nanoparticles, magnetic beads, and magnetite 
      colloidal nanocrystal clusters (CNCs) are found to be influenced by changes in 
      the stirring rate and the base molarity. The formation of magnetic beads results 
      in a decrease in the saturation magnetization, while CNCs lead to an increase in 
      saturation magnetization. On the basis of the DOE methodology and the resulting 
      3-D response surfaces for particle size and magnetic properties, it is shown that 
      optimum regions for stirring rate and molarity can be obtained to achieve coated 
      SPION with desirable size, purity, magnetization, and shape.
FAU - Mahmoudi, Morteza
AU  - Mahmoudi M
AD  - Institute for Nanoscience and Nanotechnology, Sharif University of Technology, 
      Tehran, Iran.
FAU - Simchi, Abdolreza
AU  - Simchi A
FAU - Imani, Mohammad
AU  - Imani M
FAU - Milani, Abbas S
AU  - Milani AS
FAU - Stroeve, Pieter
AU  - Stroeve P
LA  - eng
PT  - Journal Article
DEP - 20080826
PL  - United States
TA  - J Phys Chem B
JT  - The journal of physical chemistry. B
JID - 101157530
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Dextrans)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Oxides)
RN  - 9002-89-5 (Polyvinyl Alcohol)
RN  - E1UOL152H7 (Iron)
RN  - G6N3J05W84 (ferumoxides)
RN  - XM0M87F357 (Ferrosoferric Oxide)
SB  - IM
MH  - *Coated Materials, Biocompatible
MH  - Dextrans
MH  - *Diagnostic Imaging
MH  - *Drug Delivery Systems
MH  - Ferrosoferric Oxide
MH  - Iron/*chemistry
MH  - Magnetics
MH  - Magnetite Nanoparticles
MH  - Microscopy, Electron, Transmission
MH  - *Nanoparticles
MH  - Oxides/*chemistry
MH  - *Polyvinyl Alcohol
MH  - Spectrophotometry, Ultraviolet
MH  - Spectroscopy, Fourier Transform Infrared
EDAT- 2008/08/30 09:00
MHDA- 2009/01/24 09:00
CRDT- 2008/08/30 09:00
PHST- 2008/08/30 09:00 [pubmed]
PHST- 2009/01/24 09:00 [medline]
PHST- 2008/08/30 09:00 [entrez]
AID - 10.1021/jp803016n [doi]
PST - ppublish
SO  - J Phys Chem B. 2008 Nov 20;112(46):14470-81. doi: 10.1021/jp803016n. Epub 2008 
      Aug 26.