PMID- 1873433 OWN - NLM STAT- MEDLINE DCOM- 19910925 LR - 20200304 IS - 0957-5243 (Print) IS - 0957-5243 (Linking) VI - 2 IP - 1 DP - 1991 Jan TI - The epidemiology of HTLV-I infection. PG - 37-52 AB - It has been 10 years since the discovery of the human T-cell lymphotropic virus type I (HTLV-I), the first human retrovirus. During the past decade, significant progress has been made in understanding the transmission of the virus and defining its geographic distribution. It has been shown conclusively that HTLV-I is a causal factor in the induction of both adult T-cell leukemia/lymphoma and HTLV-I-associated myelopathy. However, the pathogenesis of each of these conditions is not clear, and in the light of the evidence of immune dysfunction seen among carriers of the infection, it is likely that other associated diseases will be identified. The challenge in the next decade will be to develop and implement therapeutic interventions among carriers to prevent such diseases as well as to curtail transmission within endemic populations. FAU - Mueller, N AU - Mueller N AD - Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115. LA - eng GR - R37CA38450/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PT - Review PL - Netherlands TA - Cancer Causes Control JT - Cancer causes & control : CCC JID - 9100846 SB - IM MH - HTLV-I Infections/*epidemiology/transmission MH - Humans MH - Leukemia-Lymphoma, Adult T-Cell/epidemiology/physiopathology MH - Paraparesis, Tropical Spastic/epidemiology/physiopathology RF - 185 EDAT- 1991/01/01 00:00 MHDA- 1991/01/01 00:01 CRDT- 1991/01/01 00:00 PHST- 1991/01/01 00:00 [pubmed] PHST- 1991/01/01 00:01 [medline] PHST- 1991/01/01 00:00 [entrez] AID - 10.1007/BF00052359 [doi] PST - ppublish SO - Cancer Causes Control. 1991 Jan;2(1):37-52. doi: 10.1007/BF00052359.