PMID- 1873809
OWN - NLM
STAT- MEDLINE
DCOM- 19910923
LR  - 20061115
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 51
IP  - 17
DP  - 1991 Sep 1
TI  - Defective provirus form of human T-cell leukemia virus type I in adult T-cell 
      leukemia/lymphoma: clinicopathological features.
PG  - 4639-42
AB  - Human T-cell leukemia virus type I (HTLV-I) is associated with adult T-cell 
      leukemia/lymphoma (ATLL). To examine the relationship between defective HTLV-I 
      proviruses and clinicopathological features, we examined 95 patients with ATLL 
      showing clonal integration of HTLV-I proviral DNA; 77 patients (81%) showed 1 
      clonal band, 15 (16%) showed 2 clonal bands, and 3 (3%) showed 3 clonal bands. In 
      addition, the defective proviral form was detected in 28 patients (29%): 23 (30%) 
      of the 77 with 1 clonal band, 4(27%) of the 15 with 2 clonal bands, and 1(33%) of 
      the 3 with 3 clonal bands. The numbers of clonal bands had no association with 
      the presence of defective proviruses. We classified the 95 patients with ATLL 
      into four types according to clinicopathological features (smoldering leukemia, 
      chronic leukemia, acute leukemia, and lymphoma types). The distribution of 
      patients with the defective form was not different among these four types. The 
      HTLV-I genomes must have integrated into the human genome DNA and been deleted 
      partially in the cells. The defective form was kept during the clinical stage. 
      All patients with the defective form showed defect of the gag or/and env region. 
      No patient had a defect of the pX region. These data suggest that the pX region 
      of HTLV-I must have played an important role in ATLL genesis.
FAU - Ohshima, K
AU  - Ohshima K
AD  - Department of Pathology, School of Medicine, Fukuoka University, Japan.
FAU - Kikuchi, M
AU  - Kikuchi M
FAU - Masuda, Y
AU  - Masuda Y
FAU - Kobari, S
AU  - Kobari S
FAU - Sumiyoshi, Y
AU  - Sumiyoshi Y
FAU - Eguchi, F
AU  - Eguchi F
FAU - Mohtai, H
AU  - Mohtai H
FAU - Yoshida, T
AU  - Yoshida T
FAU - Takeshita, M
AU  - Takeshita M
FAU - Kimura, N
AU  - Kimura N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Amino Acid Sequence
MH  - DNA, Viral/*analysis
MH  - Defective Viruses/*genetics
MH  - Humans
MH  - Immunophenotyping
MH  - Leukemia, T-Cell/classification/*genetics/microbiology
MH  - Lymphoma/classification/*genetics/microbiology
MH  - Molecular Sequence Data
MH  - Phenotype
MH  - Polymerase Chain Reaction
MH  - Proviruses/*genetics
EDAT- 1991/09/01 00:00
MHDA- 1991/09/01 00:01
CRDT- 1991/09/01 00:00
PHST- 1991/09/01 00:00 [pubmed]
PHST- 1991/09/01 00:01 [medline]
PHST- 1991/09/01 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1991 Sep 1;51(17):4639-42.